Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Simon’s minimax and optimal and Jung’s admissible two-stage design with or without curtailment
AU - Kunz, Cornelia
AU - Kieser, Meinhard
PY - 2011
Y1 - 2011
N2 - This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.
AB - This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561–569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.
KW - st0227
KW - simontwostage
KW - Simon’s two-stage design
KW - Jung’s admissible design
KW - phase II trials
KW - conditional power
KW - curtailment
M3 - Journal article
VL - 11
SP - 240
EP - 254
JO - Stata Journal
JF - Stata Journal
SN - 1536-867X
IS - 2
ER -