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Stochastic dynamics of remote knock-on permeation in biological ion channels

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

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Stochastic dynamics of remote knock-on permeation in biological ion channels. / Tindjong, Rodrigue; Kaufman, Igor; Luchinsky, Dmitrii G. et al.
Noise and Fluctuations (ICNF), 2013 22nd International Conference on. ed. / J.M. Routoure; L. Varani; F. Pascal. Piscataway, N.J.: IEEE, 2013.

Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Conference contribution/Paper › peer-review

Harvard

Tindjong, R, Kaufman, I, Luchinsky, DG, McClintock, PVE, Khovanov, IA & Eisenberg, RS 2013, Stochastic dynamics of remote knock-on permeation in biological ion channels. in JM Routoure, L Varani & F Pascal (eds), Noise and Fluctuations (ICNF), 2013 22nd International Conference on. IEEE, Piscataway, N.J. https://doi.org/10.1109/ICNF.2013.6578893

APA

Tindjong, R., Kaufman, I., Luchinsky, D. G., McClintock, P. V. E., Khovanov, I. A., & Eisenberg, R. S. (2013). Stochastic dynamics of remote knock-on permeation in biological ion channels. In J. M. Routoure, L. Varani, & F. Pascal (Eds.), Noise and Fluctuations (ICNF), 2013 22nd International Conference on IEEE. https://doi.org/10.1109/ICNF.2013.6578893

Vancouver

Tindjong R, Kaufman I, Luchinsky DG, McClintock PVE, Khovanov IA, Eisenberg RS. Stochastic dynamics of remote knock-on permeation in biological ion channels. In Routoure JM, Varani L, Pascal F, editors, Noise and Fluctuations (ICNF), 2013 22nd International Conference on. Piscataway, N.J.: IEEE. 2013 doi: 10.1109/ICNF.2013.6578893

Author

Tindjong, Rodrigue ; Kaufman, Igor ; Luchinsky, Dmitrii G. et al. / Stochastic dynamics of remote knock-on permeation in biological ion channels. Noise and Fluctuations (ICNF), 2013 22nd International Conference on. editor / J.M. Routoure ; L. Varani ; F. Pascal. Piscataway, N.J. : IEEE, 2013.

Bibtex

@inproceedings{115c71742c304a24b9642cc091dbb7a3,
title = "Stochastic dynamics of remote knock-on permeation in biological ion channels",
abstract = "Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape.",
author = "Rodrigue Tindjong and Igor Kaufman and Luchinsky, {Dmitrii G.} and McClintock, {Peter V. E.} and Khovanov, {I. A.} and Eisenberg, {R. S.}",
year = "2013",
doi = "10.1109/ICNF.2013.6578893",
language = "English",
isbn = "9781479906680",
editor = "J.M. Routoure and L. Varani and F. Pascal",
booktitle = "Noise and Fluctuations (ICNF), 2013 22nd International Conference on",
publisher = "IEEE",

}

RIS

TY - GEN

T1 - Stochastic dynamics of remote knock-on permeation in biological ion channels

AU - Tindjong, Rodrigue

AU - Kaufman, Igor

AU - Luchinsky, Dmitrii G.

AU - McClintock, Peter V. E.

AU - Khovanov, I. A.

AU - Eisenberg, R. S.

PY - 2013

Y1 - 2013

N2 - Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape.

AB - Brownian dynamics simulations provide evidence for a remote knock-on mechanism facilitating the permeation of a biological ion channel by an ion that is initially trapped at the selectivity filter (SF). Unlike the case of conventional direct knock-on, the second ion that instigates permeation does not need to enter the channel. Nor does it necessarily take the place of the permeating ion at the SF, and it can even be of a different ionic species. The study is based on the simultaneous, self-consistent, solution of the coupled Poisson and Langevin equations for a simple generic model, taking account of all the charges present. The new permeation mechanism involves electrostatic amplification attributable to the permittivity mismatch between water and protein: the arrival of the instigating ion at the channel entrance reduces the exit barrier for the ion trapped at the SF, facilitating escape.

U2 - 10.1109/ICNF.2013.6578893

DO - 10.1109/ICNF.2013.6578893

M3 - Conference contribution/Paper

SN - 9781479906680

BT - Noise and Fluctuations (ICNF), 2013 22nd International Conference on

A2 - Routoure, J.M.

A2 - Varani, L.

A2 - Pascal, F.

PB - IEEE

CY - Piscataway, N.J.

ER -