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Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. / Clayton, Emily; Ackerley, Jacob; Aelmans, Marianne et al.
In: Viruses, Vol. 14, No. 2, 418, 17.02.2022.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Clayton, E, Ackerley, J, Aelmans, M, Ali, N, Ashcroft, Z, Ashton, C, Barker, R, Budryte, V, Burrows, C, Cai, S, Callaghan, A, Carberry, J, Chatwin, R, Davies, I, Farlow, C, Gamblin, S, Iacobut, A, Lambe, A, Lynch, F, Mihalache, D, Mokbel, A, Potamsetty, S, Qadir, Z, Soden, J, Sun, X, Vasile, A, Wheeler, O, Rohaim, MA & Munir, M 2022, 'Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2', Viruses, vol. 14, no. 2, 418. https://doi.org/10.3390/v14020418

APA

Clayton, E., Ackerley, J., Aelmans, M., Ali, N., Ashcroft, Z., Ashton, C., Barker, R., Budryte, V., Burrows, C., Cai, S., Callaghan, A., Carberry, J., Chatwin, R., Davies, I., Farlow, C., Gamblin, S., Iacobut, A., Lambe, A., Lynch, F., ... Munir, M. (2022). Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. Viruses, 14(2), Article 418. https://doi.org/10.3390/v14020418

Vancouver

Clayton E, Ackerley J, Aelmans M, Ali N, Ashcroft Z, Ashton C et al. Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. Viruses. 2022 Feb 17;14(2):418. doi: 10.3390/v14020418

Author

Clayton, Emily ; Ackerley, Jacob ; Aelmans, Marianne et al. / Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2. In: Viruses. 2022 ; Vol. 14, No. 2.

Bibtex

@article{13a578b898fc43609cea5777588c1479,
title = "Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2",
abstract = "The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.",
keywords = "SARS-CoV-2, zoonotic, transmission, ACE2, eradication",
author = "Emily Clayton and Jacob Ackerley and Marianne Aelmans and Noor Ali and Zoe Ashcroft and Clara Ashton and Robert Barker and Vakare Budryte and Callum Burrows and Shanshan Cai and Alex Callaghan and Jake Carberry and Rebecca Chatwin and Isabella Davies and Chloe Farlow and Samuel Gamblin and Aida Iacobut and Adam Lambe and Francesca Lynch and Diana Mihalache and Amani Mokbel and Santosh Potamsetty and Zara Qadir and Jack Soden and Xiaohan Sun and Alexandru Vasile and Otto Wheeler and Rohaim, {Mohammed A.} and Muhammad Munir",
year = "2022",
month = feb,
day = "17",
doi = "10.3390/v14020418",
language = "English",
volume = "14",
journal = "Viruses",
issn = "1999-4915",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Structural Bases of Zoonotic and Zooanthroponotic Transmission of SARS-CoV-2

AU - Clayton, Emily

AU - Ackerley, Jacob

AU - Aelmans, Marianne

AU - Ali, Noor

AU - Ashcroft, Zoe

AU - Ashton, Clara

AU - Barker, Robert

AU - Budryte, Vakare

AU - Burrows, Callum

AU - Cai, Shanshan

AU - Callaghan, Alex

AU - Carberry, Jake

AU - Chatwin, Rebecca

AU - Davies, Isabella

AU - Farlow, Chloe

AU - Gamblin, Samuel

AU - Iacobut, Aida

AU - Lambe, Adam

AU - Lynch, Francesca

AU - Mihalache, Diana

AU - Mokbel, Amani

AU - Potamsetty, Santosh

AU - Qadir, Zara

AU - Soden, Jack

AU - Sun, Xiaohan

AU - Vasile, Alexandru

AU - Wheeler, Otto

AU - Rohaim, Mohammed A.

AU - Munir, Muhammad

PY - 2022/2/17

Y1 - 2022/2/17

N2 - The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.

AB - The emergence of multiple variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights the importance of possible animal-to-human (zoonotic) and human-to-animal (zooanthroponotic) transmission and potential spread within animal species. A range of animal species have been verified for SARS-CoV-2 susceptibility, either in vitro or in vivo. However, the molecular bases of such a broad host spectrum for the SARS-CoV-2 remains elusive. Here, we structurally and genetically analysed the interaction between the spike protein, with a particular focus on receptor binding domains (RBDs), of SARS-CoV-2 and its receptor angiotensin-converting enzyme 2 (ACE2) for all conceivably susceptible groups of animals to gauge the structural bases of the SARS-CoV-2 host spectrum. We describe our findings in the context of existing animal infection-based models to provide a foundation on the possible virus persistence in animals and their implications in the future eradication of COVID-19.

KW - SARS-CoV-2

KW - zoonotic

KW - transmission

KW - ACE2

KW - eradication

U2 - 10.3390/v14020418

DO - 10.3390/v14020418

M3 - Journal article

C2 - 35216011

VL - 14

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 2

M1 - 418

ER -