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The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation

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The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. / Galeb, Hanaa; Lamantia, Angelo; Robson, Alexander et al.

In: Macromolecular Chemistry and Physics, Vol. 223, No. 6, 2100489, 17.03.2022.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Galeb, H, Lamantia, A, Robson, A, König, K, Eichhorn, J, Baldock, S, Ashton, M, Baum, J, Mort, R, Robinson, B, Schacher, F, Chechik, V, Taylor, A & Hardy, J 2022, 'The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation', Macromolecular Chemistry and Physics, vol. 223, no. 6, 2100489. https://doi.org/10.1002/macp.202100489

APA

Vancouver

Galeb H, Lamantia A, Robson A, König K, Eichhorn J, Baldock S et al. The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. Macromolecular Chemistry and Physics. 2022 Mar 17;223(6):2100489. Epub 2022 Feb 10. doi: 10.1002/macp.202100489

Author

Galeb, Hanaa ; Lamantia, Angelo ; Robson, Alexander et al. / The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation. In: Macromolecular Chemistry and Physics. 2022 ; Vol. 223, No. 6.

Bibtex

@article{3e2333164221437e886c973d3122a826,
title = "The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation",
abstract = "Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.",
keywords = "melanin, pyomelanin, organic electronics, conjugated polymers, alkaptonuria",
author = "Hanaa Galeb and Angelo Lamantia and Alexander Robson and Katja K{\"o}nig and Jonas Eichhorn and Sara Baldock and Mark Ashton and John Baum and Richard Mort and Benjamin Robinson and Felix Schacher and Victor Chechik and Adam Taylor and John Hardy",
year = "2022",
month = mar,
day = "17",
doi = "10.1002/macp.202100489",
language = "English",
volume = "223",
journal = "Macromolecular Chemistry and Physics",
issn = "1022-1352",
publisher = "Wiley-VCH Verlag",
number = "6",

}

RIS

TY - JOUR

T1 - The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation

AU - Galeb, Hanaa

AU - Lamantia, Angelo

AU - Robson, Alexander

AU - König, Katja

AU - Eichhorn, Jonas

AU - Baldock, Sara

AU - Ashton, Mark

AU - Baum, John

AU - Mort, Richard

AU - Robinson, Benjamin

AU - Schacher, Felix

AU - Chechik, Victor

AU - Taylor, Adam

AU - Hardy, John

PY - 2022/3/17

Y1 - 2022/3/17

N2 - Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.

AB - Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.

KW - melanin

KW - pyomelanin

KW - organic electronics

KW - conjugated polymers

KW - alkaptonuria

U2 - 10.1002/macp.202100489

DO - 10.1002/macp.202100489

M3 - Journal article

VL - 223

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

SN - 1022-1352

IS - 6

M1 - 2100489

ER -