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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - The Polymerization of Homogentisic Acid In Vitro as a Model for Pyomelanin Formation
AU - Galeb, Hanaa
AU - Lamantia, Angelo
AU - Robson, Alexander
AU - König, Katja
AU - Eichhorn, Jonas
AU - Baldock, Sara
AU - Ashton, Mark
AU - Baum, John
AU - Mort, Richard
AU - Robinson, Benjamin
AU - Schacher, Felix
AU - Chechik, Victor
AU - Taylor, Adam
AU - Hardy, John
PY - 2022/3/17
Y1 - 2022/3/17
N2 - Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.
AB - Melanins are a class of biopolymers that are widespread in nature, with diverse origins, compositions, and functions, and their chemical and optoelectronic properties render them potentially useful for application in materials science for various biotechnological applications. For patients with alkaptonuria, the accumulation of homogentisic acid (HGA) in their bodies is associated with the concomitant deposition of pyomelanin, which is a pigment that contains significant amounts of polymerized HGA (polyHGA) in the bodily tissues of the patients. The polymerization of HGA under various different conditions in vitro is investigated using a selection of different analytical chemistry techniques to understand if there may be a correlation between the conditions and pigment deposition in vivo, and their potential for application as green/sustainable and components of electronic devices.
KW - melanin
KW - pyomelanin
KW - organic electronics
KW - conjugated polymers
KW - alkaptonuria
U2 - 10.1002/macp.202100489
DO - 10.1002/macp.202100489
M3 - Journal article
VL - 223
JO - Macromolecular Chemistry and Physics
JF - Macromolecular Chemistry and Physics
SN - 1022-1352
IS - 6
M1 - 2100489
ER -