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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - ZATT, TDP2, and SUMO2: Breaking the tie that binds TOP2 to DNA
AU - Hall, Steven Robert
AU - Goralski, Kerry B
PY - 2018/4/26
Y1 - 2018/4/26
N2 - Invited Editorial Article. First paragraph: "Type II topoisomerase (TOP2) poisons are widely used chemotherapeutics that work by disrupting the cycle of TOP2-DNA interactions that are required for DNA synthesis, gene expression, and the maintenance of genome integrity. Schellenberg et al.’s recent Science paper, entitled “ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA protein cross-links” provides a major advancement in the understanding of the mechanisms that regulate TOP2-DNA interactions, and how they can inhibit the anticancer effects of TOP2 poisons. Through these new insights, promising new therapeutic targets have been identified."
AB - Invited Editorial Article. First paragraph: "Type II topoisomerase (TOP2) poisons are widely used chemotherapeutics that work by disrupting the cycle of TOP2-DNA interactions that are required for DNA synthesis, gene expression, and the maintenance of genome integrity. Schellenberg et al.’s recent Science paper, entitled “ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA protein cross-links” provides a major advancement in the understanding of the mechanisms that regulate TOP2-DNA interactions, and how they can inhibit the anticancer effects of TOP2 poisons. Through these new insights, promising new therapeutic targets have been identified."
U2 - 10.21037/tcr.2018.02.03
DO - 10.21037/tcr.2018.02.03
M3 - Journal article
VL - 7
SP - 1412
EP - 1416
JO - Translational Cancer Research
JF - Translational Cancer Research
IS - 4
ER -