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Medical and Pharmaceutical Statistics Research Unit

  1. 2009
  2. Published

    Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme.

    Whitehead, J., Kelly, P., Zhou, Y., Stallard, N., Thygesen, H. & Bowman, C., 10/2009, In: Pharmaceutical Statistics. 8, 4, p. 287-300 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Non-compartmental estimation of pharmacokinetic parameters in serial sampling designs.

    Wolfsegger, M. J. & Jaki, T., 10/2009, In: Journal of Pharmacokinetics and Pharmacodynamics. 36, 5, p. 479-494

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Assessing differential effects: Applying regression mixture models to identify variations in the influence of family resources on academic achievement.

    Van Horn, M. L., Jaki, T., Maysn, K., Ramey, S. L., Smith, J. A. & Antaramian, S., 09/2009, In: Developmental Psychology. 45, 5, p. 1298-1313 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    A theoretical framework for estimation of AUCs in complete and incomplete sampling designs.

    Jaki, T. & Wolfsegger, M. J., 05/2009, In: Statistics in Biopharmaceutical Research. 1, 2, p. 176-184 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Using a problem-based approach to teach statistics to postgraduate science students : a case study.

    Jaki, T. & Autin, M., 05/2009, In: MSOR Connections. 9, 2, p. 40-47 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    A simple two-stage design for quantitative responses with appliction to a study in diabectic neuropathic pain.

    Whitehead, J., Valdés-Márquez, E. & Lissmats, A., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 125-135 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline.

    Bolland, K., Whitehead, J., Cobo, E. & Secades, J. J., 04/2009, In: Pharmaceutical Statistics. 8, 2, p. 136-149 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    Using historical lesion volume data in the design of a new phase II clinical trial in acute stroke.

    Whitehead, J., Bolland, K., Valdés-Márquez, E., Lihic, A., Ali, M. & Lees, K., 04/2009, In: Stroke. 40, 4, p. 1347-1352 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    One- and two-stage design proposals for a phase II trial comparing three active treatments with control using an ordered categorical endpoint.

    Whitehead, J. & Jaki, T., 28/02/2009, In: Statistics in Medicine. 28, 5, p. 828-847 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    Meta-analysis of individual patient data versus aggregate data from longitudinal clinical trials.

    Jones, A., Riley, R., Williamson, P. & Whitehead, A., 02/2009, In: Clinical Trials. 6, 1, p. 16-27 12 p.

    Research output: Contribution to journalJournal article

  12. Published

    Confidence Intervals for Ratios of AUC's in the Case of Serial Sampling : A Comparison of Seven Methods.

    Jaki, T., Wolfsegger, M. J. & Ploner, M., 01/2009, In: Pharmaceutical Statistics. 8, 1, p. 12-24 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. 2008
  14. Published

    Fitting models for the joint action of two drugs using SAS(R).

    Whitehead, A., Whitehead, J., Todd, S., Zhou, Y. & Smith, M. K., 10/2008, In: Pharmaceutical Statistics. 7, 4, p. 272-284 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Estimation following selection of the largest of two normal means. Journal of Statistical Planning and Inference 138, 1629-1638.

    Stallard, N., Todd, S. & Whitehead, J., 1/07/2008, In: Journal of Statistical Planning and Inference. 138, 6, p. 1629-1638 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    A safety monitoring procesure for a clinical drug development programme, with application to the accessment of a novel COX-2 inhibitor.

    Bolland, K., Whitehead, J. & Oldham, M., 07/2008, In: Journal of Biopharmaceutical Statistics. 18, 4, p. 737-749 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Bayesian sample size for exploratory clinical trials incorporating historical data.

    Whitehead, J., Valdés-Márquez, E., Johnson, P. & Graham, G., 06/2008, In: Statistics in Medicine. 27, 13, p. 2307-2327 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. Published

    Sequentially testing for a gene-drug interaction in a genomewide analysis.

    Kelly, P., Zhou, Y., Whitehead, J., Stallard, N. & Bowman, C., 20/05/2008, In: Statistics in Medicine. 27, 11, p. 2022-2034 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Incorporating intermediate binary responses into interim analyses of clinical trials : a comparison of four methods.

    Whitehead, A., Sooriyarachchi, M. R., Whitehead, J. & Bolland, K., 10/05/2008, In: Statistics in Medicine. 27, 10, p. 1646-1666 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Published

    Using Multilevel Mixtures to Evaluate Intervention Effects in Group Randomized Trials.

    Van Horn, M. L., Fagan, A. A., Jaki, T., Brown, E. C., Hawkins, J. D., Arthur, M. W., Abbott, R. D. & Catalano, R. F., 04/2008, In: Multivariate Behavioral Research. 43, 2, p. 289-326 38 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Implementation of a Bayesian design in a dose-escalation study of an experimental agent in healthy volunteers.

    Whitehead, J., Korhonen, P., Mustonen, M. & Zhou, Y., 03/2008, In: Biometrics. 64, 1, p. 299-308 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Active-control trials with binary data: a comparison of methods for testing superiority or non-inferiority using the odds ratio.

    Siqueira, A., Whitehead, A. & Todd, S., 10/02/2008, In: Statistics in Medicine. 27, 3, p. 353-370 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Book review: Applied Nonparametric Statistical Methods.

    Jaki, T., 2008, In: Journal of Biopharmaceutical Statistics. 18, 2, p. 393-395 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    Maximum kernel likelihood estimation

    Jaki, T. & West, R. W., 2008, In: Journal of Computational and Graphical Statistics. 17, 4, p. 976-993 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. 2007
  26. Published

    A Bayesian approach for dose-escalation in a phase I clinical trial incorporating pharmacodynamic endpoints .

    Whitehead, J., Hampson, L., Zhou, Y., Ledent, E. & Pereira, A., 11/2007, In: Journal of Biopharmaceutical Statistics. 17, 6, p. 1117-1129 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    The effect of selective decontamination of the digestive tract on mortality in multiple trauma patients: a multicenter randomized controlled trial.

    The Working Group on Selective Decontamination of the Digestive Tract, 02/2007, In: Intensive Care Medicine. 33, 2, p. 261-270 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Strategies to prevent falls and fractures in hospitals and care homes and effect of cognitive impairment: systematic review and meta- analysis.

    Oliver, D., Connelly, J. B., Victor, C. R. & Whitehead, A., 13/01/2007, In: BMJ. 334, 7584, p. 82-85 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. 2006
  30. Published

    Sequential genome-wide association studies for monitoring adverse events in clinical evaluation of new drugs.

    Whitehead, J., Kelly, P. J., Stallard, N., Zhou, Y. & Bowman, C., 30/09/2006, In: Statistics in Medicine. 25, 18, p. 3081-3092 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Published

    The sequential analysis of repeated binary responses: a score test for the case of three time points.

    Sooriyarachchi, M. R., Whitehead, J., Whitehead, A. & Bolland, K., 15/07/2006, In: Statistics in Medicine. 25, 13, p. 2196-2214 19 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Published

    Simultaneous confidence intervals by iteratively adjusted alpha for relative effects in the one-way layout.

    Wolfsegger, M. J. & Jaki, T., 2006, In: Statistics and Computing. 16, 1, p. 15-23 9 p.

    Research output: Contribution to journalJournal articlepeer-review

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