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Dr Christopher Gaffney

Senior Lecturer in Integrative Physiology

  1. Chapter (peer-reviewed)
  2. Published

    Minimizing Muscle Atrophy

    Gaffney, C., Etheridge, T. & Szewczyk, N., 28/07/2020, Handbook of Life Support Systems for Spacecraft and Extraterrestrial Habitats. Shayler, D. J. & Seedhouse, E. (eds.). Cham: Springer, p. 1-27 27 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNChapter (peer-reviewed)peer-review

  3. Conference contribution/Paper
  4. Published

    Commercial access for UK/ESA student experiments on board the ISS

    Gaffney, C., Nartallo, R., Neri, G., Zolesi, D., Torregrossa, R., Deane, C., Whiteman, M., Etheridge, T., Ellwood, R., Cooke, M., Gharahdaghi, N., Piasecki, M., Phillips, B. & Szewczyk, N., 15/04/2020, Proceedings of the 3rd Symposium on Space Educational Activities. Leicester: University of Leicester, p. 152-154 3 p.

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNConference contribution/Paper

  5. Abstract
  6. Published

    EXPLORING DIFFERENCES IN ELECTROMYOGRAPHY AND GROUND REACTION FORCES BETWEEN FRONT AND BACK SQUATS BEFORE AND AFTER A FATIGUING PROTOCOL

    Rattley, C., Gaffney, C. & Bampouras, T., 23/07/2022, ISBS Proceedings Archive. International Society of Biomechanics in Sports, 5 p. 138. (ISBS Proceedings Archive; vol. 40, no. 1).

    Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSNAbstract

  7. Poster
  8. Published

    NemaLife Machine: An automated microfluidic system for whole-life studies in C. elegans

    Anupom, T., Rahman, M., Gupta, S., Edwards, H., Soni, P., LeBlanc, M., Koblah, D., Gaffney, C., Etheridge, T., Szewczyk, N., Driscoll, M. & Vanapalli, S. A., 20/06/2019.

    Research output: Contribution to conference - Without ISBN/ISSN Poster

  9. Abstract
  10. Published

    MUSCLE ACTIVITY ASSOCIATED WITH PERFORMING ROBOT- ASSISTED AND CONVENTIONAL LAPAROSCOPY

    Shugaba, A., Lambert, J., Nuttall, H. E., Subar, D., Gaffney, C. & Bampouras, T., 29/06/2022.

    Research output: Contribution to conference - Without ISBN/ISSN Abstractpeer-review

  11. Forthcoming

    Cannabidiol (CBD) may influence substrate utilisation during and muscle recovery following damaging exercise

    Gaffney, C., Cunnington, J., Greathead, N., Rigby, E., Scott, D., Montemayor, M., Garvey, H. & Wright, K., 24/04/2022, (Accepted/In press).

    Research output: Contribution to conference - Without ISBN/ISSN Abstractpeer-review

  12. Published

    Laparoscopic skills Acquisition in obstetrics and Gynaecology and General Surgical trainees (LAGGS)

    Khan, Z., Shrestha, D., Shugaba, A., Gaffney, C., Afors, K., Clark, J. & Subar, D., 21/04/2022.

    Research output: Contribution to conference - Without ISBN/ISSN Abstractpeer-review

  13. Published

    Our experience with national and international outreach and engagement for #wormsinspace

    Deane, C., Gaffney, C., Etheridge, T., Szewczyk, N. & Phillips, B., 27/04/2019.

    Research output: Contribution to conference - Without ISBN/ISSN Abstract

  14. Published

    C. elegans as a model for understanding spaceflight induced muscle decline

    Pollard, A., Gaffney, C., Deane, C., Cooke, M., Hewitt, J., Phillips, B., Szewczyk, N., Vanapalli, S. & Etheridge, T., 18/06/2018.

    Research output: Contribution to conference - Without ISBN/ISSN Abstractpeer-review

  15. Web publication/site
  16. Published

    Cancer: getting in shape before surgery can shorten hospital stays

    Keegan, T. & Gaffney, C., 16/09/2021

    Research output: Exhibits, objects and web-based outputsWeb publication/site

  17. Published

    High-intensity workouts may put regular gym goers at risk of rhabdomyolysis, a rare but dangerous condition

    Gaffney, C., 17/07/2020

    Research output: Exhibits, objects and web-based outputsWeb publication/site

  18. Doctoral Thesis
  19. Unpublished

    The impact of physiological stressors on mitochondrial function in Caenorhabditis elegans and in humans

    Gaffney, C. J., 2015, (Unpublished) University of Nottingham. 281 p.

    Research output: ThesisDoctoral Thesis

  20. Other contribution
  21. Published

    Space Race 2.0: Hostile Space

    Gaffney, C., 8/05/2019, Down to Earth.

    Research output: Other contribution

  22. Published

    Worms in space: why we are launching them

    Gaffney, C. & Phillips, B., 3/12/2018, The Conversation.

    Research output: Other contribution

  23. Journal article
  24. Published

    Should all minimal access surgery be robot-assisted? A systematic review into the musculoskeletal and cognitive demands of laparoscopic and robot-assisted laparoscopic surgery

    Shugaba, A., Lambert, J., Bampouras, T., Nuttall, H. E., Gaffney, C. & Subar, D., 31/07/2022, In: Journal of Gastrointestinal Surgery. 26, 7, p. 1520-1530 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. Forthcoming
  26. Published

    BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα

    Owens, L., Bracewell, J., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 5/04/2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1201-1220 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. Published

    Weighted vests in CrossFit increase physiological stress during walking and running without changes in spatiotemporal gait parameters

    Gaffney, C., Cunnington, J., Rattley, C., Wrench, E., Dyche, C. & Bampouras, T., 31/01/2022, In: Ergonomics. 65, 1, p. 147-158 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    Recent Progress and Perspectives on Non-Invasive Glucose Sensors

    Davison, N., Gaffney, C., Kerns, J. & Zhuang, Q., 12/01/2022, In: Diabetology. 3, 1, p. 56-71 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. Published

    Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

    Yasar, Z., Elliott, B., Kyriakidou, Y., Nwokoma, C., Postlethwaite, R., Gaffney, C., Dewhurst, S. & Hayes, L., 31/07/2021, In: European Journal of Applied Physiology. 121, 7, p. 1909-1919 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  30. Published

    Short-Term Immobilization Promotes a Rapid Loss of Motor Evoked Potentials and Strength That Is Not Rescued by rTMS Treatment

    Gaffney, C., Drinkwater, A., Joshi, S. D., O'Hanlon, B., Robinson, A., Sands, K-A., Slade, K., Braithwaite, J. J. & Nuttall, H. E., 26/04/2021, In: Frontiers in Human Neuroscience. 15, 640642.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  31. Published

    Spaceflight Affects Neuronal Morphology and Alters Transcellular Degradation of Neuronal Debris in Adult Caenorhabditis elegans

    Laranjeiro, R., Harinath, G., Pollard, A. K., Gaffney, C., Deane, C., Vanapalli, S., Etheridge, T., Szewczyk, N. J. & Driscoll, M., 19/02/2021, In: iScience. 24, 2, 36 p., 102105.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  32. Published

    Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

    Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  33. E-pub ahead of print

    The impact of prehabilitation on patient outcomes in hepatobiliary, colorectal, and upper gastrointestinal cancer surgery: a PRISMA-accordant meta-analysis

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 12/11/2020, (E-pub ahead of print) In: Annals of Surgery. 0, p. 0-0

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  34. Published

    Molecular Muscle Experiment: Hardware and Operational Lessons for Future Astrobiology Space Experiments

    Pollard, A., Gaffney, C., Deane, C., Balsamo, M., Cooke, M., Ellwood, R., Hewitt, J., Mierzwa, B., Mariani, A., Vanapalli, S. A., Etheridge, T. & Szewczyk, N. J., 6/08/2020, In: Astrobiology. 20, 8, p. 935-943 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  35. E-pub ahead of print

    Effect of acute and short-term dietary fat ingestion on postprandial skeletal muscle protein synthesis rates in middle-aged, overweight and obese men

    Tsintzas, K., Jones, R., Pabla, P., Mallinson, J., Barrett, D., Kim, D-H., Cooper, S., Davies, A., Taylor, T., Gaffney, C., Chee, C., van Loon, L. & Stephens, F., 7/01/2020, (E-pub ahead of print) In: American Journal of Physiology - Endocrinology and Metabolism.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  36. Published

    Muscle strength deficiency and mitochondrial dysfunction in a muscular dystrophy model of C. elegans and its functional response to drugs

    Hewitt, J., Pollard, A., Lesanpezeshki, L., Deane, C., Gaffney, C. J., Etheridge, T., Szewczyk, N. & Vanapalli, S., 31/12/2018, In: Disease Models & Mechanisms. 11, 11, 13 p., 36137.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  37. Published

    Worms in Space for Outreach on Earth: Space Life Science Activities for the Classroom

    Gaffney, C. J., Pollard, A., Deane, C., Cooke, M., Balsamo, M., Hewitt, J., Vanapalli, S., Szewczyk, N., Etheridge, T. & Phillips, B., 2018, In: Gravitational and Space Research. 6, 2, p. 74-82 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  38. Published

    Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans

    Gaffney, C. J., Pollard, A., Barratt, T., Constantin-Teodosiu, D., Greenhaff, P. L. & Szewczyk, N., 2018, In: Aging. 10, 11, p. 3382—3396 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  39. Published

    The effect of long-term confinement and the efficacy of exercise countermeasures on muscle strength during a simulated mission to Mars: data from the Mars500 study

    Gaffney, C. J., Fomina, E., Babich, D., Kitov, V., Uskov, K. & Green, D. A., 13/11/2017, In: Sports Medicine - Open. 3, 1, 11 p., 40.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  40. Published

    FGF21 Is an Insulin-Dependent Postprandial Hormone in Adult Humans

    Samms, R. J., Lewis, J. E., Norton, L., Stephens, F. B., Gaffney, C. J., Butterfield, T., Smith, D. P., Cheng, C. C., Perfield, J. W., Adams, A. C., Ebling, F. J. P. & Tsintzas, K., 1/10/2017, In: Journal of Clinical Endocrinology and Metabolism. 102, 10, p. 3806-3813 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  41. Published

    Exercise Metabolism in Nonobese Patients with Type 2 Diabetes Following the Acute Restoration of Normoglycaemia

    Gaffney, C. J., Mansell, P., Stephens, F. B., Macdonald, I. A. & Tsintzas, K., 29/05/2017, In: Journal of Diabetes Research. 2017, 8 p., 8248725.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  42. Published

    Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development

    Mora-Lorca, J. A., Sáenz-Narciso, B., Gaffney, C. J., Naranjo-Galindo, F. J., Pedrajas, J. R., Guerrero-Gómez, D., Dobrzynska, A., Askjaer, P., Szewczyk, N. J., Cabello, J. & Miranda-Vizuete, A., 07/2016, In: Free Radical Biology and Medicine. 96, p. 446-461 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  43. Published

    Degenerin channel activation causes caspase-mediated protein degradation and mitochondrial dysfunction in adult C. elegans muscle

    Gaffney, C. J., Shephard, F., Chu, J., Baillie, D. L., Rose, A., Constantin-Teodosiu, D., Greenhaff, P. L. & Szewczyk, N. J., 05/2016, In: Journal of Cachexia, Sarcopenia and Muscle. 7, 2, p. 181-192 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  44. Published

    The integrin-adhesome is required to maintain muscle structure, mitochondrial ATP production, and movement forces in Caenorhabditis elegans

    Etheridge, T., Rahman, M., Gaffney, C. J., Shaw, D., Shephard, F., Magudia, J., Solomon, D. E., Milne, T., Blawzdziewicz, J., Constantin-Teodosiu, D., Greenhaff, P. L., Vanapalli, S. A. & Szewczyk, N. J., 04/2015, In: FASEB Journal. 29, 4, p. 1235-1246 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  45. Published

    Methods to assess subcellular compartments of muscle in C. elegans

    Gaffney, C. J., Bass, J. J., Barratt, T. F. & Szewczyk, N. J., 13/11/2014, In: Journal of Visualized Experiments. 93, p. e52043

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  46. Published

    Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases

    Muñoz-Lobato, F., Rodríguez-Palero, M. J., Naranjo-Galindo, F. J., Shephard, F., Gaffney, C. J., Szewczyk, N. J., Hamamichi, S., Caldwell, K. A., Caldwell, G. A., Link, C. D. & Miranda-Vizuete, A., 10/01/2014, In: Antioxidants and Redox Signaling. 20, 2, p. 217-235 19 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  47. Letter
  48. Published

    Response to: (Comment on “The impact of prehabilitation on patient outcomes in hepatobiliary, colorectal and Upper Gastro-intestinal cancer surgery: A PRISMA-Accordant Meta-Analysis”)

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 31/12/2021, In: Annals of Surgery. 274, 6, p. e932-e933 2 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

  49. Published

    Response to “Comment on Prehabilitation in Major Abdominal Surgery”

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 31/12/2021, In: Annals of Surgery. 274, 6, p. e944-e945 2 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

  50. Published

    Response to the Comment on "The Impact of Prehabilitation on Patient Outcomes in Hepatobiliary, Colorectal and Upper Gastrointestinal Cancer Surgery: A PRISMA-Accordant Meta-analysis"

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 31/12/2021, In: Annals of Surgery. 274, 6, p. e932-e933 2 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

  51. Published

    Response to: (Comment on “The impact of prehabilitation on patient outcomes in hepatobiliary, colorectal and Upper Gastro-intestinal cancer surgery: A PRISMA-Accordant Meta-Analysis”)

    Lambert, J., Hayes, L., Keegan, T., Subar, D. & Gaffney, C., 6/12/2021, In: Annals of Surgery. 274, 6, p. e946-e947 2 p.

    Research output: Contribution to Journal/MagazineLetterpeer-review

  52. Meeting abstract
  53. Published

    Mitochondria-targeting hydrogen sulfide donors prolong healthspan: lifespan ratio in Caenorhabditis elegans

    Etheridge, T., Gaffney, C., Szewczyk, N., Torregrossa, R., Wood, M. E. & Whiteman, M., 11/2017, In: Free Radical Biology and Medicine. 112, Suppl. 1, p. 51-51 1 p.

    Research output: Contribution to Journal/MagazineMeeting abstractpeer-review

  54. Review article
  55. Published

    There is no dose–response relationship between the amount of exercise and improvement in HbA1c in interventions over 12 weeks in patients with type 2 diabetes: a meta-analysis and meta-regression

    Wrench, E., Rattley, K., Lambert, J. E., Killick, R., Hayes, L. D., Lauder, R. M. & Gaffney, C. J., 30/11/2022, In: Acta Diabetologica. 59, 11, p. 1399-1415 17 p.

    Research output: Contribution to Journal/MagazineReview articlepeer-review

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