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Research

Dr Edward Parkin

Senior Lecturer in Biomedicine

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  1. 2025
  2. Published

    Updating public facing Defying Dementia web pages

    Parkin, E., 23/06/2025

    Research output: Exhibits, objects and web-based outputs › Web publication/site

  3. 2024
  4. Published

    Progress towards understanding risk factor mechanisms in the development of autism spectrum disorders

    Bryers, A., Hawkes, C. A., Parkin, E. & Dawson, N., 30/10/2024, In: Biochemical Society Transactions. 52, 5, p. 2047-2058 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  5. Published

    Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease

    Armstrong, P., Güngör, H., Anongjanya, P., Tweedy, C., Parkin, E., Johnston, J., Carr, I. M., Dawson, N. & Clapcote, S. J., 09/2024, In: Neuropsychopharmacology. 49, 10, p. 1559-1568 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  6. Published

    Liposome nanoparticle conjugation and cell penetrating peptide sequences ( CPPs ) enhance the cellular delivery of the tau aggregation inhibitor RI ‐ AG03

    Reich, N., Parkin, E. & Dawson, N., 1/06/2024, In: Journal of Cellular and Molecular Medicine. 28, 11, e18477.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  7. 2022
  8. Published

    BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα

    Owens, L., Bracewell, J., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 5/04/2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1201-1220 20 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  9. Published

    The Amyloid Precursor Protein Plays Differential Roles in the UVA Resistance and Proliferation of Human Retinal Pigment Epithelial Cells

    Sultan, F. & Parkin, E., 30/03/2022, In: Protein and Peptide Letters. 29, 4, p. 313-327 15 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  10. Published

    The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein

    Parkin, E. T., Hammond, J. E., Owens, L. & Hodges, M. D., 13/01/2022, In: PLoS ONE. 17, 1, 21 p., e0255715.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  11. 2021
  12. Published

    Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

    Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  13. 2018
  14. Published

    Osteonectin as a screening marker for pancreatic cancer: A prospective study

    Papapanagiotou, A., Sgourakis, G., Karkoulias, K., Raptis, D., Parkin, E. T., Brotzakis, P., Panchal, S. & Papavassiliou, A., 1/07/2018, In: Journal of International Medical Research. 46, 7, p. 2769-2779 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  15. 2016
  16. Published

    Notch Signalling as a Therapeutic Target in Cancer

    Martinas, I. & Parkin, E. T., 10/2016, In: International Journal of Cancer Therapy and Oncology. 4, 4

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  17. Published

    Pyruvate dehydrogenase kinase inhibition: reversing the Warburg effect in cancer therapy

    Bell, H. & Parkin, E. T., 23/06/2016, In: International Journal of Cancer Therapy and Oncology. 4, 2, p. 4215-4227 12 p.

    Research output: Contribution to Journal/Magazine › Literature review › peer-review

  18. Published

    Stroma-induced Jagged1 expression drives PC3 prostate cancer cell migration: disparate effects of RIP-generated proteolytic fragments on cell behaviour and Notch signaling

    Delury, C. P., Hart, C., Brown, M., Clarke, N. & Parkin, E. T., 25/03/2016, In: Biochemical and Biophysical Research Communications. 472, 1, p. 255-261 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  19. 2015
  20. Published

    The E1 copper binding domain of full-length amyloid precursor protein promotes epithelial to mesenchymal transition in DU145 cells in isoform-specific manner

    Gough, M., Delury, C. & Parkin, E., 2015, In: International Journal of Biochemistry Research and Review. 6, 1, p. 264-273 10 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  21. Published

    The histidine composition of the amyloid-β domain, but not the E1 copper binding domain, modulates β-secretase processing of amyloid-β protein precursor in Alzheimer's disease

    Gough, M., Blanthorn-Hazell, S. & Parkin, E. T., 2015, In: Journal of Alzheimer's Disease. 43, 4, p. 1163-1168 6 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  22. 2014
  23. Published

    The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

    Gough, M., Blanthorn-Hazell, S., Delury, C. & Parkin, E., 31/10/2014, In: Biochemical and Biophysical Research Communications. 453, 4, p. 741-747 7 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  24. 2013
  25. Published

    The amyloid precursor protein represses expression of acetylcholinesterase in neuronal cell lines

    Hicks, D. A., Makova, N. Z., Gough, M., Parkin, E. T., Nalivaeva, N. N. & Turner, A. J., 6/09/2013, In: Journal of Biological Chemistry. 288, 36, p. 26039-26051 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  26. Published

    Differential regulation of E-cadherin expression by the soluble ectodomain and intracellular domain of jagged1

    Delury, C., Tinker, C., Rivers, S., Hodges, M., Broughton, S. & Parkin, E., 2/08/2013, In: International Journal of Biochemistry Research and Review. 3, 4, p. 278-290 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  27. 2012
  28. Published

    Copper modulates zinc metalloproteinase-dependent ectodomain shedding of key signalling and adhesion proteins and promotes the invasion of prostate cancer epithelial cells

    Parr-Sturgess, C. A., Tinker, C. L., Hart, C. A., Brown, M. D., Clarke, N. W. & Parkin, E. T., 10/2012, In: Molecular Cancer Research. 10, 10, p. 1282-1293 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  29. 2011
  30. Published

    Zinc metalloproteinases and amyloid Beta-Peptide metabolism: the positive side of proteolysis in Alzheimer's disease

    Gough, M., Parr-Sturgess, C. & Parkin, E., 2011, In: Biochemistry Research International. 2011, 13 p., 721463.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  31. 2010
  32. Published

    Development of a proteolytically stable retro-inverso peptide inhibitor of β-amyloid oligomerization as a potential novel treatment for Alzheimer's disease

    Taylor, M., Moore, S., Mayes, J., Parkin, E., Beeg, M., Canovi, M., Gobbi, M., Mann, D. M. A. & Allsop, D., 2010, In: Biochemistry. 49, 15, p. 3261-3272 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  33. Published

    Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

    Parr-Sturgess, C. A., Rushton, D. J. & Parkin, E. T., 2010, In: Biochemical Journal. 432, 2, p. 283-294 12 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  34. 2009
  35. Published

    Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

    Harris, B., Pereira, I. & Parkin, E., 16/10/2009, In: Brain Research. 1296, n/a, p. 203-215 13 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  36. Published

    Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein

    Taylor, D. R., Parkin, E. T., Cocklin, S. L., Ault, J. R., Ashcroft, A. E., Turner, A. J. & Hooper, N. M., 21/08/2009, In: Journal of Biological Chemistry. 284, 34, p. 22590-22600 11 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  37. Published

    A disintegrin and metalloproteinase (ADAM)-mediated ectodomain shedding of ADAM10

    Parkin, E. & Harris, B., 03/2009, In: Journal of Neurochemistry. 108, 6, p. 1464-1479 16 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

  38. 2008
  39. Published

    Membrane raft actin deficiency and altered Ca2+-induced vesiculation in stomatin-deficient overhydrated hereditary stomatocytosis

    Wilkinson, D. K., Turner, E. J., Parkin, E. T., Garner, A. E., Harrison, P. J., Crawford, M., Stewart, G. W. & Hooper, N. M., 01/2008, In: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1778, 1, p. 125-132 8 p.

    Research output: Contribution to Journal/Magazine › Journal article › peer-review

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