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Discrete conductance levels in calcium channel models: multiband calcium selective conduction

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Article number1836-Plat
<mark>Journal publication date</mark>29/01/2013
<mark>Journal</mark>Biophysical Journal
Issue number2, Suppl. 1
Number of pages1
Pages (from-to)358a
Publication StatusPublished
<mark>Original language</mark>English


Brownian dynamics were simulated for the simple model of calcium channels introduced by Nonner and Eisenberg, computing electric forces from all charges. Permanent charge (of acidic side chains) was varied. Substantial conduction was found only at certain discrete values of permanent charge. Different con-duction states had different selectivity, one resembling L-type CaV1 and the other RyR channels. We speculate that thermally acti-vated switching between conductance values could produce some types of spon-taneous gating. Below is calcium current J as a function of permanent charge Qf and calcium concentration.