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Discrete conductance levels in calcium channel models: multiband calcium selective conduction

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Discrete conductance levels in calcium channel models: multiband calcium selective conduction. / Eisenberg, Robert S.; Kaufman, Igor; Luchinsky, Dmitrii G. et al.
In: Biophysical Journal, Vol. 104, No. 2, Suppl. 1, 1836-Plat, 29.01.2013, p. 358a.

Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

Harvard

Eisenberg, RS, Kaufman, I, Luchinsky, DG, Tindjong, R & McClintock, PVE 2013, 'Discrete conductance levels in calcium channel models: multiband calcium selective conduction', Biophysical Journal, vol. 104, no. 2, Suppl. 1, 1836-Plat, pp. 358a. https://doi.org/10.1016/j.bpj.2012.11.1989

APA

Eisenberg, R. S., Kaufman, I., Luchinsky, D. G., Tindjong, R., & McClintock, P. V. E. (2013). Discrete conductance levels in calcium channel models: multiband calcium selective conduction. Biophysical Journal, 104(2, Suppl. 1), 358a. Article 1836-Plat. https://doi.org/10.1016/j.bpj.2012.11.1989

Vancouver

Eisenberg RS, Kaufman I, Luchinsky DG, Tindjong R, McClintock PVE. Discrete conductance levels in calcium channel models: multiband calcium selective conduction. Biophysical Journal. 2013 Jan 29;104(2, Suppl. 1):358a. 1836-Plat. doi: 10.1016/j.bpj.2012.11.1989

Author

Eisenberg, Robert S. ; Kaufman, Igor ; Luchinsky, Dmitrii G. et al. / Discrete conductance levels in calcium channel models : multiband calcium selective conduction. In: Biophysical Journal. 2013 ; Vol. 104, No. 2, Suppl. 1. pp. 358a.

Bibtex

@article{fbdebfbab6814e1da440b30018d64b9e,
title = "Discrete conductance levels in calcium channel models: multiband calcium selective conduction",
abstract = "Brownian dynamics were simulated for the simple model of calcium channels introduced by Nonner and Eisenberg, computing electric forces from all charges. Permanent charge (of acidic side chains) was varied. Substantial conduction was found only at certain discrete values of permanent charge. Different con-duction states had different selectivity, one resembling L-type CaV1 and the other RyR channels. We speculate that thermally acti-vated switching between conductance values could produce some types of spon-taneous gating. Below is calcium current J as a function of permanent charge Qf and calcium concentration.",
author = "Eisenberg, {Robert S.} and Igor Kaufman and Luchinsky, {Dmitrii G.} and Rodrigue Tindjong and McClintock, {Peter V. E.}",
year = "2013",
month = jan,
day = "29",
doi = "10.1016/j.bpj.2012.11.1989",
language = "English",
volume = "104",
pages = "358a",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Cell Press",
number = "2, Suppl. 1",

}

RIS

TY - JOUR

T1 - Discrete conductance levels in calcium channel models

T2 - multiband calcium selective conduction

AU - Eisenberg, Robert S.

AU - Kaufman, Igor

AU - Luchinsky, Dmitrii G.

AU - Tindjong, Rodrigue

AU - McClintock, Peter V. E.

PY - 2013/1/29

Y1 - 2013/1/29

N2 - Brownian dynamics were simulated for the simple model of calcium channels introduced by Nonner and Eisenberg, computing electric forces from all charges. Permanent charge (of acidic side chains) was varied. Substantial conduction was found only at certain discrete values of permanent charge. Different con-duction states had different selectivity, one resembling L-type CaV1 and the other RyR channels. We speculate that thermally acti-vated switching between conductance values could produce some types of spon-taneous gating. Below is calcium current J as a function of permanent charge Qf and calcium concentration.

AB - Brownian dynamics were simulated for the simple model of calcium channels introduced by Nonner and Eisenberg, computing electric forces from all charges. Permanent charge (of acidic side chains) was varied. Substantial conduction was found only at certain discrete values of permanent charge. Different con-duction states had different selectivity, one resembling L-type CaV1 and the other RyR channels. We speculate that thermally acti-vated switching between conductance values could produce some types of spon-taneous gating. Below is calcium current J as a function of permanent charge Qf and calcium concentration.

U2 - 10.1016/j.bpj.2012.11.1989

DO - 10.1016/j.bpj.2012.11.1989

M3 - Meeting abstract

VL - 104

SP - 358a

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 2, Suppl. 1

M1 - 1836-Plat

ER -