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Observation of "remote knock-on", a new permeation-enhancement mechanism in ion channels

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Published
<mark>Journal publication date</mark>28/01/2014
<mark>Journal</mark>Biophysical Journal
Issue number2 Suppl. 1
Volume106
Number of pages1
Pages (from-to)133A
Publication StatusPublished
<mark>Original language</mark>English
Event58th Annual Meeting of the Biophysical-Society - San Francisco, Canada
Duration: 15/02/201419/02/2014

Conference

Conference58th Annual Meeting of the Biophysical-Society
Country/TerritoryCanada
Period15/02/1419/02/14

Abstract

We report observation of a novel ‘‘remote knock-on’’ mechanism for enhancement of permeation in Brownian dynamics simulations of a simple model ion channel. Unlike conventional knock-on, which requires a second ion of the same species to enter the channel in order to knock forward and replace an ion already in the channel, the new mechanism does not require the instigating ion to enter the channel, nor that it be of the same species.