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Dr Alexandre Benedetto

Senior lecturer in Integrative Physiology

  1. Editorial
  2. Published

    In silico, in vivo

    Hardy, J., Benedetto, A. & Appleby, J., 11/09/2023, The Biologist, 70, 3, p. 14-17 4 p.

    Research output: Contribution to specialist publicationEditorial

  3. Doctoral Thesis
  4. Published
  5. Journal article
  6. Published

    Creating 3D objects with integrated electronics via multiphoton fabrication in vitro and in vivo

    Baldock, S., Kevin, P., Harper, G., Griffin, R., Genedy, H., Fong, J., Zhao, Z., Zhang, Z., Shen, Y., Lin, H., Au, C., Martin, J., Ashton, M., Haskew, M., Stewart, B., Efremova, O., Esfahani, R., Emsley, H., Appleby, J. & Cheneler, D. & 3 others, Cummings, D. M., Benedetto, A. & Hardy, J., 9/06/2023, In: Advanced Materials Technologies. 8, 11, 13 p., 2201274.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  7. Published

    Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions

    Zárate-Potes, A., Ali, I., Ribeiro Camacho, M., Brownless, H. & Benedetto, A., 10/05/2022, In: Frontiers in Microbiology. 13, 17 p., 853629.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  8. Published

    High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

    Ali, I., Martin, J., Zárate-Potes, A. & Benedetto, A., 28/04/2022, In: Journal of Visualized Experiments. 2022, 182, e63860.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  9. Published

    BACE1 Overexpression Reduces SH-SY5Y Cell Viability Through a Mechanism Distinct from Amyloid-β Peptide Accumulation: Beta Prime-Mediated Competitive Depletion of sAβPPα

    Owens, L., Bracewell, J., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 5/04/2022, In: Journal of Alzheimer's Disease. 86, 3, p. 1201-1220 20 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  10. Published

    Gene therapy-mediated enhancement of protective protein expression for the treatment of Alzheimer's disease

    Owens, L., Benedetto, A., Dawson, N., Gaffney, C. & Parkin, E., 15/02/2021, In: Brain Research. 1753, 12 p., 147264.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  11. Published

    New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging

    Benedetto, A., Bambade, T., Au, C., Tullet, J. M. A., Monkhouse, J., Dang, H., Cetnar, K., Chan, B., Cabreiro, F. & Gems, D., 1/10/2019, In: Aging Cell. 18, 5, 10 p., e12998.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  12. Published

    Autophagy promotes visceral aging in wild-type C. elegans

    Benedetto, A. & Gems, D., 3/04/2019, In: Autophagy. 15, 4, p. 737-732 2 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  13. Published

    C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies

    Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A. F., Au, C., Zhang, Q., van Schelt, S., Petrache, A. L., Wang, H., de la Guardia, Y., Bar-Nun, S., Tyler, E., Wakelam, M. J. & Gems, D., 20/08/2018, In: Current Biology. 28, 16, p. 2544-2556.e5 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  14. Published

    A parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

    Wang, H., Zhao, Y., Ezcurra, M., Benedetto, A., Gilliat, A. F., Hellberg, J., Ren, Z., Galimov, E. R., Athigapanich, T., Girstmair, J., Telford, M. J., Dolphin, C. T., Zhang, Z. & Gems, D., 13/06/2018, In: npj Aging and Mechanisms of Disease. 4, 1, 12 p., 6.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  15. Published

    Rigor mortis-like process during organismal death in c. elegans

    Galimov, E. R., Pryor, R. E., Poole, S. E., Benedetto, A., Pincus, Z. & Gems, D., 06/2018, In: Opera Medica et Physiologica. 4, p. 74 1 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  16. Published

    Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death

    Galimov, E. R., Pryor, R. E., Poole, S. E., Benedetto, A., Pincus, Z. & Gems, D., 6/03/2018, In: Cell Reports. 22, 10, p. 2730-2741 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  17. Published

    Autophagy-dependent gut-to-yolk biomass conversion generates visceral polymorbidity in aging C. elegans

    Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A., Au, C., Zhang, Q., van Schelt, S., Petrache, A. L., de la Guardia, Y., Bar-Nun, S., Tyler, E., Wakelam, M. J. & Gems, D., 15/12/2017, In: Biorxiv.

    Research output: Contribution to Journal/MagazineJournal article

  18. Published

    The SKN-1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms

    Tullet, J. M. A., Green, J. W., Au, C., Benedetto, A., Thompson, M. A., Clark, E., Gilliat, A. F., Young, A., Schmeisser, K. & Gems, D., 10/2017, In: Aging Cell. 16, 5, p. 1191-1194 4 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  19. Published

    LFASS: Label-Free Automated Survival Scoring for High-Throughput Nematode Assays

    Benedetto, A., Bambade, T., Au, C., Tullet, J., Dang, H., Cetnar, K., Cabreiro, F. & Gems, D., 28/09/2017, In: Biorxiv. 23 p.

    Research output: Contribution to Journal/MagazineJournal article

  20. Published

    Monsters in the uterus: a parthenogenetic quasi-program causes teratoma-like tumors during aging in wild-type C. elegans

    Wang, H., Zhao, Y., Ezcurra, M., Gilliat, A. F., Hellberg, J., Benedetto, A., Athigapanich, T., Girstmair, J., Telford, M., Zhang, Z. & Gems, D., 10/08/2017, In: Biorxiv. 34 p.

    Research output: Contribution to Journal/MagazineJournal article

  21. Published

    Involvement of heat shock proteins on Mn-induced toxicity in Caenorhabditis elegans

    Avila, D. S., Benedetto, A., Au, C., Bornhorst, J. & Aschner, M., 2/11/2016, In: BMC Pharmacology and Toxicology. 17, 1, 9 p., 54.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  22. Published

    In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity

    Kuriyama, S., Theveneau, E., Benedetto, A., Parsons, M., Tanaka, M., Charras, G., Kabla, A. & Mayor, R., 7/07/2014, In: Journal of Cell Biology. 206, 1, p. 113-127 15 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  23. Published

    Spatiotemporal control of gene expression using microfluidics

    Benedetto, A., Accetta, G., Fujita, Y. & Charras, G., 7/04/2014, In: Lab on a Chip. 14, 7, p. 1336-1347 12 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  24. Published

    DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans

    Tullet, J. M. A., Araiz, C., Sanders, M. J., Au, C., Benedetto, A., Papatheodorou, I., Clark, E., Schmeisser, K., Jones, D., Schuster, E. F., Thornton, J. M. & Gems, D., 6/02/2014, In: PLoS Genetics. 10, 2, 16 p., e1004109.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  25. Published

    Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans

    Coburn, C., Allman, E., Mahanti, P., Benedetto, A., Cabreiro, F., Pincus, Z., Matthijssens, F., Araiz, C., Mandel, A., Vlachos, M., Edwards, S.-A., Fischer, G., Davidson, A., Pryor, R. E., Stevens, A., Slack, F. J., Tavernarakis, N., Braeckman, B. P., Schroeder, F. C. & Nehrke, K. & 1 others, Gems, D., 23/07/2013, In: Plos Biology. 11, 7, 17 p., e1001613.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  26. Published

    Organotellurium and organoselenium compounds attenuate Mn-induced toxicity in Caenorhabditis elegans by preventing oxidative stress

    Avila, D. S., Benedetto, A., Au, C., Manarin, F., Erikson, K., Soares, F. A., Rocha, J. B. T. & Aschner, M., 1/05/2012, In: Free Radical Biology and Medicine. 52, 9, p. 1903-1910 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  27. Published

    Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms

    Aitlhadj, L., Avila, D. S., Benedetto, A., Aschner, M. & Stürzenbaum, S. R., 01/2011, In: Environmental Health Perspectives. 119, 1, p. 20-28 9 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  28. Published

    Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans

    Exil, V. J., Silva Avila, D., Benedetto, A., Exil, E. A., Adams, M. R., Au, C. & Aschner, M., 3/12/2010, In: PLoS ONE. 5, 12, 11 p., e14228.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  29. Published

    Extracellular dopamine potentiates mn-induced oxidative stress, lifespan reduction, and dopaminergic neurodegeneration in a BLI-3-dependent manner in Caenorhabditis elegans

    Benedetto, A., Au, C., Avila, D. S., Milatovic, D. & Aschner, M., 26/08/2010, In: PLoS Genetics. 6, 8

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  30. Published

    SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans

    Au, C., Benedetto, A., Anderson, J., Labrousse, A., Erikson, K., Ewbank, J. J. & Aschner, M., 18/11/2009, In: PLoS ONE. 4, 11, 17 p., e7792.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  31. Published

    Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease

    Benedetto, A., Au, C. & Aschner, M., 10/2009, In: Chemical Reviews. 109, 10, p. 4862-4884 23 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  32. Published

    Caenorhabditis elegans: an emerging model in biomedical and environmental toxicology

    Leung, M. C. K., Williams, P. L., Benedetto, A., Au, C., Helmcke, K. J., Aschner, M. & Meyer, J. N., 11/2008, In: Toxicological sciences : an official journal of the Society of Toxicology. 106, 1, p. 5-28 24 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  33. Published

    Manganese transport in eukaryotes: the role of DMT1

    Au, C., Benedetto, A. & Aschner, M., 07/2008, In: NeuroToxicology. 29, 4, p. 569-576 8 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  34. Published

    Antioxidant properties of blirubin in the model organism, Caenorhabditis elegans

    McCaughan, D., Au, C., Benedetto, A., Milatovic, D., Aschner, J. & Aschner, M., 07/2008, In: International Journal of Neuroprotection and Neuroregeneration. 4, 3, p. 252-262 11 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  35. Published

    Genes required for osmoregulation and apical secretion in Caenorhabditis elegans

    Liégeois, S., Benedetto, A., Michaux, G., Belliard, G. & Labouesse, M., 1/02/2007, In: Genetics. 175, 2, p. 709-724 16 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  36. Published

    The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans

    Liégeois, S., Benedetto, A., Garnier, J.-M., Schwab, Y. & Labouesse, M., 19/06/2006, In: Journal of Cell Biology. 173, 6, p. 949-961 13 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  37. Published

    Overexpression of toll-like receptor 4 amplifies the host response to lipopolysaccharide and provides a survival advantage in transgenic mice

    Bihl, F., Salez, L., Beaubier, M., Torres, D., Larivière, L., Laroche, L., Benedetto, A., Martel, D., Lapointe, J.-M., Ryffel, B. & Malo, D., 15/06/2003, In: Journal of Immunology. 170, 12, p. 6141-6150 10 p.

    Research output: Contribution to Journal/MagazineJournal articlepeer-review

  38. Comment/debate
  39. Published

    Erratum: C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies (Current Biology (2018) 28(16) (2544–2556.e5), (S0960982218308261) (10.1016/j.cub.2018.06.035))

    Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A. F., Au, C., Zhang, Q., van Schelt, S., Petrache, A. L., Wang, H., Guardia, Y. D. L., Bar-Nun, S., Tyler, E., Wakelam, M. J. & Gems, D., 22/10/2018, In: Current Biology. 28, 20, 1 p.

    Research output: Contribution to Journal/MagazineComment/debatepeer-review

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