Both Maternal High-Fat and Post-Weaning High-Carbohydrate Diets Increase Rates of Spontaneous Hepatocellular Carcinoma in Aged-Mouse Offspring

Holt, D., Contu, L., Wood, A., Chadwick, H., Alborelli, I., Insilla, A. C., Crea, F. & Hawkes, C. A., 22/08/2024, In: Nutrients. 16, 16, 2805.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Clearance of interstitial fluid (ISF) and CSF (CLIC) group‐part of Vascular Professional Interest Area (PIA), updates in 2022‐2023. Cerebrovascular disease and the failure of elimination of Amyloid‐β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy

Kelly, L., Brown, C., Michalik, D., Hawkes, C. A., Aldea, R., Agarwal, N., Salib, R., Alzetani, A., Ethell, D. W., Counts, S. E., de Leon, M., Fossati, S., Koronyo‐Hamaoui, M., Piazza, F., Rich, S. A., Wolters, F. J., Snyder, H., Ismail, O., Elahi, F. & Proulx, S. T. & 6 others, Verma, A., Wunderlich, H., Haack, M., Dodart, J. C., Mazer, N. & Carare, R. O., 21/02/2024, In: Alzheimer's and Dementia : the journal of the Alzheimer's Association. 20, 2, p. 1421-1435

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ ISMRM Imaging Neurofluids Study group” Workshop in Rome

Agarwal, N., Lewis, L. D., Hirschler, L., Rivera, L. R., Naganawa, S., Levendovszky, S. R., Ringstad, G., Klarica, M., Wardlaw, J., Iadecola, C., Hawkes, C., Carare, R. O., Wells, J., Bakker, E. N. T. P., Kurtcuoglu, V., Bilston, L., Nedergaard, M., Mori, Y., Stoodley, M. & Alperin, N. & 2 others, de Leon, M. & van Osch, M. J. P., 16/01/2024, In: Journal of Magnetic Resonance Imaging. 59, 2, p. 431-449 19 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia

Sri, S., Greenstein, A., Granata, A., Collcutt, A., Jochems, A. C. C., McColl, B. W., Castro, B. D., Webber, C., Reyes, C. A., Hall, C., Lawrence, C. B., Hawkes, C., Pegasiou-Davies, C.-M., Gibson, C., Crawford, C. L., Smith, C., Vivien, D., McLean, F. H., Wiseman, F. & Brezzo, G. & 37 others, Lalli, G., Pritchard, H. A. T., Markus, H. S., Bravo-Ferrer, I., Taylor, J., Leiper, J., Berwick, J., Gan, J., Gallacher, J., Moss, J., Goense, J., McMullan, L., Work, L., Evans, L., Stringer, M. S., Ashford, M. L. J., Abulfadl, M., Conlon, N., Malhotra, P., Bath, P., Canter, R., Brown, R., Ince, S., Anderle, S., Young, S., Quick, S., Szymkowiak, S., Hill, S., Allan, S., Wang, T., Quinn, T., Procter, T., Farr, T. D., Zhao, X., Yang, Z., Hainsworth, A. H. & Wardlaw, J. M., 31/12/2023, In: Cerebral Circulation - Cognition and Behavior. 5, 100189.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Appetitive Motivation and Associated Neurobiology Change Differentially across the Life Course of Mouse Offspring Exposed to Peri- and Postnatal High Fat Feeding

Contu, L., Heath, C. J. & Hawkes, C. A., 4/12/2022, In: Nutrients. 14, 23, 21 p., 5161.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression

Hawkes, C. A., Heath, C. J., Sharp, M. M., Górecki, D. C. & Carare, R. O., 31/08/2022, In: Acta Neuropathologica Communications. 10, 1, 15 p., 127.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Editorial: The Neurovascular Unit as a Potential Biomarker and Therapeutic Target in Cerebrovascular Disease

Nizari, S., Hawkes, C. A., Hattori, Y. & Mishra, A., 5/05/2022, In: Frontiers in Aging Neuroscience. 14, 2 p., 908716.

Research output: Contribution to Journal/Magazine › Editorial › peer-review

Endothelial-derived extracellular vesicles induce cerebrovascular dysfunction in inflammation

Roig-Carles, D., Willms, E., Fontijn, R. D., Martinez-Pacheco, S., Mäger, I., de Vries, H. E., Hirst, M., Sharrack, B., Male, D. K., Hawkes, C. A. & Romero, I. A., 21/09/2021, In: Pharmaceutics. 13, 9, 1525.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms

Mather, R. L., Parolia, A., Carson, S. E., Venalainen, E., Roig-Carles, D., Jaber, M., Chu, S. C., Alborelli, I., Wu, R., Lin, D., Nabavi, N., Jachetti, E., Colombo, M. P., Xue, H., Pucci, P., Ci, X., Hawkes, C., Li, Y., Pandha, H. & Ulitsky, I. & 6 others, Marconett, C., Quagliata, L., Jiang, W., Romero, I., Wang, Y. & Crea, F., 31/07/2021, In: Molecular Oncology. 15, 7, p. 1921-1941 21 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Age-related ultrastructural neurovascular changes in the female mouse cortex and hippocampus

Frías-Anaya, E., Gromnicova, R., Kraev, I., Rogachevsky, V., Male, D. K., Crea, F., Hawkes, C. A. & Romero, I. A., 31/05/2021, In: Neurobiology of Aging. 101, p. 273-284 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Loss of cholinergic innervation differentially affects eNOS-mediated blood flow, drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice

Nizari, S., Wells, J. A., Carare, R. O., Romero, I. A. & Hawkes, C. A., 7/01/2021, In: Acta Neuropathologica Communications. 9, 1, 17 p., 12.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy

Carare, R. O., Aldea, R., Agarwal, N., Bacskai, B. J., Bechman, I., Boche, D., Bu, G., Bulters, D., Clemens, A., Counts, S. E., de Leon, M., Eide, P. K., Fossati, S., Greenberg, S. M., Hamel, E., Hawkes, C. A., Koronyo-Hamaoui, M., Hainsworth, A. H., Holtzman, D. & Ihara, M. & 25 others, Jefferson, A., Kalaria, R. N., Kipps, C. M., Kanninen, K. M., Leinonen, V., McLaurin, J. A., Miners, S., Malm, T., Nicoll, J. A. R., Piazza, F., Paul, G., Rich, S. M., Saito, S., Shih, A., Scholtzova, H., Snyder, H., Snyder, P., Thormodsson, F. R., van Veluw, S. J., Weller, R. O., Werring, D. J., Wilcock, D., Wilson, M. R., Zlokovic, B. V. & Verma, A., 3/08/2020, In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. 12, 1, 7 p., e12053.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cerebrospinal fluid dynamics modulation by diet and cytokines in rats

Alimajstorovic, Z., Pascual-Baixauli, E., Hawkes, C. A., Sharrack, B., Loughlin, A. J., Romero, I. A. & Preston, J. E., 10/02/2020, In: Fluids and Barriers of the CNS. 17, 1, 10 p., 10.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Knockout of apolipoprotein A-I decreases parenchymal and vascular β-amyloid pathology in the Tg2576 mouse model of Alzheimer's disease

Contu, L., Carare, R. O. & Hawkes, C. A., 1/12/2019, In: Neuropathology and Applied Neurobiology. 45, 7, p. 698-714 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Pre- and Post-natal High Fat Feeding Differentially Affects the Structure and Integrity of the Neurovascular Unit of 16-Month Old Male and Female Mice

Contu, L., Nizari, S., Heath, C. J. & Hawkes, C. A., 2/10/2019, In: Frontiers in Neuroscience. 13, 17 p., 1045.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Immune complex formation impairs the elimination of solutes from the brain: Implications for immunotherapy in Alzheimer's disease

Carare, R. O., Teeling, J. L., Hawkes, C. A., Püntener, U., Weller, R. O., Nicoll, J. A. R. & Perry, V. H., 9/08/2019, In: Acta Neuropathologica Communications. 2, 1, 48.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

3D reconstruction of the neurovascular unit reveals differential loss of cholinergic innervation in the cortex and hippocampus of the adult mouse brain

Nizari, S., Carare, R. O., Romero, I. A. & Hawkes, C. A., 4/07/2019, In: Frontiers in Aging Neuroscience. 11, 15 p., 172.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways

Albargothy, N. J., Johnston, D. A., MacGregor-Sharp, M., Weller, R. O., Verma, A., Hawkes, C. A. & Carare, R. O., 1/07/2018, In: Acta Neuropathologica. 136, 1, p. 139-152 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology

Horsburgh, K., Wardlaw, J. M., van Agtmael, T., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davis, J. B., Duncombe, J., Farr, T. D., Fowler, J. H., Goense, J., Granata, A., Hall, C. N., Hainsworth, A. H., Harvey, A. & Hawkes, C. A. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., Macleod, M. R., Macrae, I. M., Markus, H. S., McCabe, C., McColl, B. W., Meakin, P. J., Miller, A., Nedergaard, M., O'Sullivan, M., Quinn, T. J., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R. M., Trueman, R. C., Wang, T., Williams, A., Williams, S. C. R. & Work, L. M., 30/04/2018, In: Clinical Science. 132, 8, p. 851-868 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The role of perivascular innervation and neurally mediated vasoreactivity in the pathophysiology of Alzheimer's disease

Nizari, S., Romero, I. A. & Hawkes, C. A., 1/06/2017, In: Clinical Science. 131, 12, p. 1207-1214 8 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

A review of the impact of maternal obesity on the cognitive function and mental health of the offspring

Contu, L. & Hawkes, C. A., 19/05/2017, In: International Journal of Molecular Sciences. 18, 5, 11 p., 1093.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Vascular basement membranes as pathways for the passage of fluid into and out of the brain

Morris, A. W. J., Sharp, M. M. G., Albargothy, N. J., Fernandes, R., Hawkes, C. A., Verma, A., Weller, R. O. & Carare, R. O., 1/05/2016, In: Acta Neuropathologica. 131, 5, p. 725-736 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Increased Aβ pathology in aged Tg2576 mice born to mothers fed a high fat diet

Nizari, S., Carare, R. O. & Hawkes, C. A., 25/02/2016, In: Scientific Reports. 6, 10 p., 21981.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A simulation model of periarterial clearance of amyloid-β from the brain

Diem, A. K., Tan, M., Bressloff, N. W., Hawkes, C., Morris, A. W. J., Weller, R. O. & Carare, R. O., 12/02/2016, In: Frontiers in Aging Neuroscience. 8, FEB, 11 p., 18.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Are you also what your mother eats? Distinct proteomic portrait as a result of maternal high-fat diet in the cerebral cortex of the adult mouse

Manousopoulou, A., Woo, J., Woelk, C. H., Johnston, H. E., Singhania, A., Hawkes, C., Garbis, S. D. & Carare, R. O., 6/08/2015, In: International Journal of Obesity. 39, 8, p. 1325-1328 4 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Does the difference between PART and Alzheimer’s disease lie in the age-related changes in cerebral arteries that trigger the accumulation of Aβ and propagation of tau?

Weller, R. O., Hawkes, C. A., Carare, R. O. & Hardy, J., 1/05/2015, In: Acta Neuropathologica. 129, 5, p. 763-766 4 p.

Research output: Contribution to Journal/Magazine › Letter › peer-review

Prenatal high-fat diet alters the cerebrovasculature and clearance of β-amyloid in adult offspring

Hawkes, C. A., Gentleman, S. M., Nicoll, J. A. & Carare, R. O., 1/03/2015, In: Journal of Pathology. 235, 4, p. 619-631 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

White matter changes in dementia: Role of impaired drainage of interstitial fluid

Weller, R. O., Hawkes, C. A., Kalaria, R. N., Werring, D. J. & Carare, R. O., 1/01/2015, In: Brain Pathology. 25, 1, p. 63-78 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The cerebrovascular basement membrane: Role in the clearance of β-amyloid and cerebral amyloid angiopathy

Morris, A. W. J., Carare, R. O., Schreiber, S. & Hawkes, C. A., 1/09/2014, In: Frontiers in Aging Neuroscience. 6, SEP, 9 p., 251.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Phosphodiesterase III inhibitor promotes drainage of cerebrovascular β-amyloid

Maki, T., Okamoto, Y., Carare, R. O., Hase, Y., Hattori, Y., Hawkes, C. A., Saito, S., Yamamoto, Y., Terasaki, Y., Ishibashi-Ueda, H., Taguchi, A., Takahashi, R., Miyakawa, T., Kalaria, R. N., Lo, E. H., Arai, K. & Ihara, M., 1/08/2014, In: Annals of Clinical and Translational Neurology. 1, 8, p. 519-533 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Failure of perivascular drainage of β-amyloid in cerebral amyloid angiopathy

Hawkes, C. A., Jayakody, N., Johnston, D. A., Bechmann, I. & Carare, R. O., 1/07/2014, In: Brain Pathology. 24, 4, p. 396-403 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Amyloid and tau in the brain in sporadic Alzheimer's disease: Defining the chicken and the egg

Hawkes, C. A., Carare, R. O. & Weller, R. O., 1/04/2014, In: Acta Neuropathologica. 127, 4, p. 617-618 2 p.

Research output: Contribution to Journal/Magazine › Letter › peer-review

Afferent and efferent immunological pathways of the brain. Anatomy, Function and Failure

Carare, R. O., Hawkes, C. A. & Weller, R. O., 1/02/2014, In: Brain, Behavior, and Immunity. 36, p. 9-14 6 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Hypertension drives parenchymal β-amyloid accumulation in the brain parenchyma

Bueche, C. Z., Hawkes, C., Garz, C., Vielhaber, S., Attems, J., Knight, R. T., Reymann, K., Heinze, H. J., Carare, R. O. & Schreiber, S., 1/01/2014, In: Annals of Clinical and Translational Neurology. 1, 2, p. 124-129 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

MK886 reduces cerebral amyloid angiopathy severity in TgCRND8 mice

Hawkes, C. A., Shaw, J. E., Brown, M., Sampson, A. P., McLaurin, J. & Carare, R. O., 1/12/2013, In: Neurodegenerative Diseases. 13, 1, p. 17-23 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Stroke-induced opposite and age-dependent changes of vessel-associated markers in co-morbid transgenic mice with Alzheimer-like alterations

Hawkes, C. A., Michalski, D., Anders, R., Nissel, S., Grosche, J., Bechmann, I., Carare, R. O. & Härtig, W., 1/12/2013, In: Experimental Neurology. 250, p. 270-281 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Review: Cerebral amyloid angiopathy, prion angiopathy, CADASIL and the spectrum of protein elimination failure angiopathies (PEFA) in neurodegenerative disease with a focus on therapy

Carare, R. O., Hawkes, C. A., Jeffrey, M., Kalaria, R. N. & Weller, R. O., 1/10/2013, In: Neuropathology and Applied Neurobiology. 39, 6, p. 593-611 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Regional differences in the morphological and functional effects of aging on cerebral basement membranes and perivascular drainage of amyloid-β from the mouse brain

Hawkes, C. A., Gatherer, M., Sharp, M. M., Dorr, A., Yuen, H. M., Kalaria, R., Weller, R. O. & Carare, R. O., 20/02/2013, In: Aging Cell. 12, 2, p. 224-236 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

In vivo uptake of β-amyloid by non-plaque associated microglia

Hawkes, C. A., Deng, L. H., Fenili, D., Nitz, M. & McLaurin, J. A., 26/10/2012, In: Current Alzheimer Research. 9, 8, p. 890-901 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer's disease

Dorr, A., Sahota, B., Chinta, L. V., Brown, M. E., Lai, A. Y., Ma, K., Hawkes, C. A., McLaurin, J. & Stefanovic, B., 1/10/2012, In: Brain. 135, 10, p. 3039-3050 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Single-transmembrane domain IGF-II/M6P receptor: Potential interaction with g protein and its association with cholesterol-rich membrane domains

Amritraj, A., Posse De Chaves, E. I., Hawkes, C., MacDonald, R. G. & Kar, S., 1/10/2012, In: Endocrinology. 153, 10, p. 4784-4798 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele

Hawkes, C. A., Sullivan, P. M., Hands, S., Weller, R. O., Nicoll, J. A. R. & Carare, R. O., 25/07/2012, In: PLoS ONE. 7, 7, e41636.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

S1P is associated with protection in human and experimental cerebral malaria

Finney, C. A. M., Hawkes, C. A., Kain, D. C., Dhabangi, A., Musoke, C., Cserti-Gazdewich, C., Oravecz, T., Conrad Liles, W. & Kain, K. C., 1/07/2011, In: Molecular Medicine. 17, 7-8, p. 717-725 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

Hawkes, C. A., Härtig, W., Kacza, J., Schliebs, R., Weller, R. O., Nicoll, J. A. & Carare, R. O., 1/04/2011, In: Acta Neuropathologica. 121, 4, p. 431-443 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Small molecule β-amyloid inhibitors that stabilize protofibrillar structures in vitro improve cognition and pathology in a mouse model of Alzheimer's disease

Hawkes, C. A., Deng, L. H., Shaw, J. E., Nitz, M. & McLaurin, J., 1/01/2010, In: European Journal of Neuroscience. 31, 2, p. 203-213 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Small molecule inhibitors of Aβ-aggregation and neurotoxicity

Hawkes, C. A., Ng, V. & McLaurin, J., 1/03/2009, In: Drug Development Research. 70, 2, p. 111-124 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy

Hawkes, C. A. & McLaurin, J., 27/01/2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 4, p. 1261-1266 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Altered levels and distribution of IGF-II/M6P receptor and lysosomal enzymes in mutant APP and APP + PS1 transgenic mouse brains

Amritraj, A., Hawkes, C., Phinney, A. L., Mount, H. T., Scott, C. D., Westaway, D. & Kar, S., 1/01/2009, In: Neurobiology of Aging. 30, 1, p. 54-70 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Clinical immunotherapy trials in Alzheimer's disease

Hawkes, C. A. & McLaurin, J. A., 1/09/2008, In: Drug Discovery Today: Therapeutic Strategies. 5, 3, p. 177-183 7 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

Sun, Y., Zhang, G., Hawkes, C. A., Shaw, J. E., McLaurin, J. A. & Nitz, M., 1/08/2008, In: Bioorganic and Medicinal Chemistry. 16, 15, p. 7177-7184 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Expression microarray analysis implicates apoptosis and interferon-responsive mechanisms in susceptibility to experimental cerebral malaria

Lovegrove, F. E., Gharib, S. A., Patel, S. N., Hawkes, C. A., Kain, K. C. & Liles, W. C., 1/12/2007, In: American Journal of Pathology. 171, 6, p. 1894-1903 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Immunotherapy as treatment for Alzheimer's disease

Hawkes, C. A. & McLaurin, J., 1/11/2007, In: Expert Review of Neurotherapeutics. 7, 11, p. 1535-1548 14 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Heterotrimeric G proteins and the single-transmembrane domain IGF-II/M6P receptor: Functional interaction and relevance to cell signaling

Hawkes, C., Amritraj, A., MacDonald, R. G., Jhamandas, J. H. & Kar, S., 1/06/2007, In: Molecular Neurobiology. 35, 3, p. 329-345 17 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Effect of kainic acid treatment on insulin-like growth factor-2 receptors in the IGF2-deficient adult mouse brain

Dikkes, P., Hawkes, C., Kar, S. & Lopez, M. F., 2/02/2007, In: Brain Research. 1131, 1, p. 77-87 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Up-regulation of cation-independent mannose 6-phosphate receptor and endosomal-lysosomal markers in surviving neurons after 192-IgG-saporin administrations into the adult rat brain

Hawkes, C., Kabogo, D., Amritraj, A. & Kar, S., 1/10/2006, In: American Journal of Pathology. 169, 4, p. 1140-1154 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cyclohexanehexol inhibitors of Aβ aggregation prevent and reverse Alzheimer phenotype in a mouse model

McLaurin, J. A., Kierstead, M. E., Brown, M. E., Hawkes, C. A., Lambermon, M. H. L., Phinney, A. L., Darabie, A. A., Cousins, J. E., French, J. E., Lan, M. F., Chen, F., Wong, S. S. N., Mount, H. T. J., Fraser, P. E., Westaway, D. & George-Hyslop, P. S., 1/07/2006, In: Nature Medicine. 12, 7, p. 801-808 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3β

Li, T., Hawkes, C., Qureshi, H. Y., Kar, S. & Paudel, H. K., 1/03/2006, In: Biochemistry. 45, 10, p. 3134-3145 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Cellular distribution of insulin-like growth factor-II/mannose-6-phosphate receptor in normal human brain and its alteration in Alzheimer's disease pathology

Kar, S., Poirier, J., Guevara, J., Dea, D., Hawkes, C., Robitaille, Y. & Quirion, R., 1/02/2006, In: Neurobiology of Aging. 27, 2, p. 199-210 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Single transmembrane domain insulin-like growth factor-II/mannose-6- phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway

Hawkes, C., Jhamandas, J. H., Harris, K. H., Fu, W., MacDonald, R. G. & Kar, S., 11/01/2006, In: Journal of Neuroscience. 26, 2, p. 585-596 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Selective loss of basal forebrain cholinergic neurons by 192 IgG-saporin is associated with decreased phosphorylation of Ser9 glycogen synthase kinase-3β

Hawkes, C., Jhamandas, J. H. & Kar, S., 1/10/2005, In: Journal of Neurochemistry. 95, 1, p. 263-272 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The insulin-like growth factor-II/mannose-6-phosphate receptor: Structure, distribution and function in the central nervous system

Hawkes, C. & Kar, S., 1/03/2004, In: Brain Research Reviews. 44, 2-3, p. 117-140 24 p.

Research output: Contribution to Journal/Magazine › Review article › peer-review

Insulin-like growth factor-II/mannose-6-phosphate receptor: Widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype

Hawkes, C. & Kar, S., 31/03/2003, In: Journal of Comparative Neurology. 458, 2, p. 113-127 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Insulin-like growth factor-II/mannose-6-phosphate receptor in the spinal cord and dorsal root ganglia of the adult rat

Hawkes, C. & Kar, S., 31/01/2002, In: European Journal of Neuroscience. 15, 1, p. 33-39 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review