Transferability Of Ancestry-Specific And Cross-Ancestry CYP2A6 Activity Genetic Risk Scores In African And European Populations

El-Boraie, A., Chenoweth, M. J., Pouget, J. G., Benowitz, N. L., Fukunaga, K., Mushiroda, T., Kubo, M., Nollen, N. L., Cox, L. S., Lerman, C., Knight, J. & Tyndale, R. F., 31/10/2021, In: Clinical pharmacology and therapeutics. 110, 4, p. 975-985 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelou, E., Warren, H. R., Mosen-Ansorena, D., Mifsud, B., Pazoki, R., Gao, H., Ntritsos, G., Dimou, N., Cabrera, C. P., Karaman, I., Ng, F. L., Evangelou, M., Witkowska, K., Tzanis, E., Hellwege, J. N., Giri, A., Velez Edwards, D. R., Sun, Y. V., Cho, K., Gaziano, J. M., & 31 othersWilson, P. W. F., Tsao, P. S., Kovesdy, C. P., Esko, T., Mägi, R., Milani, L., Almgren, P., Boutin, T., Debette, S., Ding, J., Giulianini, F., Holliday, E. G., Jackson, A. U., Li-Gao, R., Lin, W-Y., Luan, J., Mangino, M., Oldmeadow, C., Prins, B. P., Qian, Y., Sargurupremraj, M., Shah, N., Surendran, P., Thériault, S., Verweij, N., Willems, S. M., Zhao, J-H., Amouyel, P., Connell, J., Knight, J. & Million Veteran Program, 17/09/2018, In: Nature Genetics. 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genetic epistasis regulates amyloid deposition in resilient aging

Felsky, D., Xu, J., Chibnik, L., Schneider, J., Knight, J., Kennedy, J. L., Bennett, D. A., De Jager, P. L. & Voineskos, A. N., 10/2017, In: Alzheimer's and Dementia. 13, 10, p. 1107-1116 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene

Flomen, R., Knight, J., Sham, P., Kerwin, R. & Makoff, A., 1/04/2004, In: Nucleic Acids Research. 32, 7, p. 2113-2122 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Age at onset in sod1-mediated amyotrophic lateral sclerosis shows familiality

Fogh, I., Rijsdijk, F., Andersen, P. M., Sham, P. C., Knight, J., Neale, B., McKenna-Yasek, D., Silani, V., Brown, R. H., Powell, J. F. & Al-Chalabi, A., 08/2007, In: Neurogenetics. 8, 3, p. 235-236 2 p.

Research output: Contribution to Journal/Magazine › Letter › peer-review

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 03/2016, In: Nature Reviews Neuroscience. 19, 3, p. 420-431 12 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS

Gagliano, S. A., Ptak, C., Mak, D. Y. F., Shamsi, M., Oh, G., Knight, J., Boutros, P. C. & Petronis, A., 5/05/2016, In: American Journal of Human Genetics. 98, 5, p. 956-962 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Smoking gun or circumstantial evidence? comparison of statistical learning methods using functional annotations for prioritizing risk variants

Gagliano, S. A., Ravji, R., Barnes, M. R., Weale, M. E. & Knight, J., 24/08/2015, In: Scientific Reports. 5, 11 p., 13373.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Assessing models for genetic prediction of complex traits: a comparison of visualization and quantitative methods

Gagliano, S. A., Paterson, A. D., Weale, M. E. & Knight, J., 22/05/2015, In: BMC Genomics. 16, 11 p., 405.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization

Gagliano, S. A., Barnes, M. R., Weale, M. E. & Knight, J., 20/05/2014, In: PLoS ONE. 9, 5, 14 p., e98122.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Protein kinase cAMP-dependent regulatory type II beta (PRKAR2B) gene variants in antipsychotic-induced weight gain

Gagliano, S. A., Tiwari, A. K., Freeman, N., Lieberman, J. A., Meltzer, H. Y., Kennedy, J. L., Knight, J. & Müller, D. J., 07/2014, In: Human Psychopharmacology: Clinical and Experimental. 29, 4, p. 330-335 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s diseases

Gagliano, S. A., Pouget, J. G., Hardy, J., Knight, J., Barnes, M. R., Ryten, M. & Weale, M., 12/2016, In: Annals of Clinical and Translational Neurology. 3, 12, p. 924-933 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

TTF-1 and RET promoter SNPs: regulation of RET transcription in Hirschsprung's disease

Garcia-Barcelo, M., Ganster, R. W., Lui, V. C. H., Leon, T. Y. Y., So, M-T., Lau, A. M. F., Fu, M., Sham, M-H., Knight, J., Zannini, M. S., Sham, P. C. & Tam, P. K. H., 15/01/2005, In: Human Molecular Genetics. 14, 2, p. 191-204 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Impact of digital technology in care homes on Emergency Department attendances

Garner, A., Knight, J., Preston, N., Dixon, S., Watchorn, S., Caiado, C., McShane, C., King, G. & Mason, S., 22/11/2022, In: Emergency Medicine Journal. 39, 12, 1 p., A974.

Research output: Contribution to Journal/Magazine › Meeting abstract

The impact of digital technology in care homes on unplanned secondary care usage and associated costs

Garner, A., Lewis, J., Dixon, S., Preston, N., Caiado, C. C. S., Hanratty, B., Jones, M., Knight, J. & Mason, S. M., 29/02/2024, In: Age and Ageing. afae004.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Understanding health service utilisation patterns for care home residents during the COVID-19 pandemic using routinely collected healthcare data

Garner, A., Preston, N., Caiado, C. C. S., Stubington, E., Hanratty, B., Limb, J., Mason, S. M. & Knight, J., 23/05/2024, In: BMC Geriatrics. 24, 1, 449.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian randomization study

Giratallah, H., Chenoweth, M. J., Pouget, J. G., El-Boraie, A., Alsaafin, A., Lerman, C., Knight, J. & Tyndale, R. F., 15/01/2024, In: Human Molecular Genetics. 33, 2, p. 198-210

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Examining the role of common and rare mitochondrial variants in schizophrenia

Gonçalves, V. F., Giamberardino, S. N., Crowley, J. J., Vawter, M. P., Saxena, R., Bulik, C. M., Yilmaz, Z., Hultman, C. M., Sklar, P., Kennedy, J. L., Sullivan, P. F. & Knight, J., 25/01/2018, In: PLoS ONE. 13, 1, e0191153.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 6/11/2014, In: American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2018, In: Nature Genetics. 50, 4, p. 538-548 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Polymorphisms in the phosphate and tensin homolog gene are not associated with late-onset Alzheimer's disease

Hamilton, G., Samedi, F., Knight, J., Archer, N., Foy, C., Walter, S., Turic, D., Jehu, L., Moore, P., Hollingworth, P., O'Donovan, M. C., Williams, J., Owen, M. J., Lovestone, S. & Powell, J. F., 19/06/2006, In: Neuroscience Letters. 401, 1-2, p. 77-80 4 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Endothelial nitric oxide gene haplotypes and risk of cerebral small-vessel disease

Hassan, A. E. M., Gormley, K., O'Sullivan, M., Knight, J., Sham, P. C., Vallance, P., Bamford, J. & Markus, H. S., 03/2004, In: Stroke; a journal of cerebral circulation. 35, 3, p. 654-659 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Analyzing the Role of MicroRNAs in Schizophrenia in the Context of Common Genetic Risk Variants

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 04/2016, In: JAMA Psychiatry. 73, 4, p. 369-377 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Estimating Effect Sizes and Expected Replication Probabilities from GWAS Summary Statistics

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 16/02/2016, In: Frontiers in Genetics. 7, 13 p., 15.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Fine-mapping inflammatory bowel disease loci to single-variant resolution

Huang, H., Fang, M., Jostins, L., Umićević Mirkov, M., Boucher, G., Anderson, C. A., Andersen, V., Cleynen, I., Cortes, A., Crins, F., D'Amato, M., Deffontaine, V., Dmitrieva, J., Docampo, E., Elansary, M., Farh, K. K-H., Franke, A., Gori, A-S., Goyette, P., Halfvarson, J., & 27 othersHaritunians, T., Knight, J., Lawrance, I. C., Lees, C. W., Louis, E., Mariman, R., Meuwissen, T., Mni, M., Momozawa, Y., Parkes, M., Spain, S. L., Théâtre, E., Trynka, G., Satsangi, J., van Sommeren, S., Vermeire, S., Xavier, R. J., Weersma, R. K., Duerr, R. H., Mathew, C. G., Rioux, J. D., McGovern, D. P. B., Cho, J. H., Georges, M., Daly, M. J., Barrett, J. C. & International Inflammatory Bowel Disease Genetics Consortium, 13/07/2017, In: Nature. 547, 7662, p. 173-178 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Are child health information services a viable source of accurate vaccination data for clinicians working in paediatric emergency departments in England?

Isba, R., Davies, N. & Knight, J., 31/12/2021, In: BMJ Health Care and Informatics. 28, 1, 3 p., e100486.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Measles, mumps, and rubella vaccination coverage in children younger than 5 years attending a paediatric emergency department in Manchester, UK: a cross-sectional observational study

Isba, R., Brennan, L., Davies, N. & Knight, J., 25/11/2022, In: The Lancet. 400 , Suppl 1, p. S51 1 p.

Research output: Contribution to Journal/Magazine › Meeting abstract › peer-review

Unmet vaccination need among children under the age of five attending the paediatric emergency department: a cross-sectional study in a large UK district general hospital

Isba, R., Brennan, L., Egboko, F., Edge, R., Davies, N. & Knight, J., 27/06/2023, In: BMJ Open. 13, 6, e072053.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Numbers and types of neurological emergencies in England and the influence of socioeconomic deprivation: a retrospective analysis of hospital episode statistics data

Jackson, M., Szczepaniak, M., Wall, J., Maskery, M., Mummery, C., Morrish, P., Williams, A., Knight, J. & Emsley, H. C. A., 4/11/2022, In: BMJ Open. 12, 11, 7 p., e061843.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study

Schizophrenia Working Group of the Psychiatric Genomics Consortium, 28/10/2016, In: PLoS Genetics. 12, 10, 20 p., e1006343.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A modelling framework for developing early warning systems of COPD emergency admissions

Johnson, O., Knight, J. & Giorgi, E., 1/02/2021, In: Spatial and Spatio-temporal Epidemiology. 36, 9 p., 100392.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

COVID-19 exposes the urgent need for coding of outpatient neurology episodes

Kemp, M., Biggin, F., Dayanandan, R., Knight, J. & Emsley, H. C. A., 31/08/2020, In: BMJ Neurology Open. 2, 2, 2 p., e000080.

Research output: Contribution to Journal/Magazine › Editorial › peer-review

IBD genetic risk profile in healthy first-degree relatives of Crohn's disease patients

Kevans, D., Silverberg, M. S., Borowski, K., Griffiths, A., Xu, W., Onay, V., Paterson, A. D., Knight, J., Croitoru, K. & GEM Project, 02/2016, In: Journal of Crohn's and Colitis. 10, 2, p. 209-215 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Conditional analysis identifies three novel major histocompatibility complex loci associated with psoriasis

Knight, J., Spain, S. L., Capon, F., Hayday, A., Nestle, F. O., Clop, A., Barker, J. N. W. N., Weale, M. E., Trembath, R. C. & Wellcome Trust Case Control Consortium, 1/12/2012, In: Human Molecular Genetics. 21, 23, p. 5185-5192 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Human chromosome 17 in essential hypertension

Knight, J., Munroe, P. B., Pembroke, J. C. & Caulfield, M. J., 03/2003, In: Annals of Human Genetics. 67, 2, p. 193-206 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Investigation of chromosome 17q as a locus for human essential hypertension in African Caribbeans

Knight, J., Gardner, G. T., Clark, A. J. & Caulfield, M. J., 06/2000, In: Journal of Human Hypertension. 14, 6, p. 385-387 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

CLUMPHAP: a simple tool for performing haplotype-based association analysis

Knight, J., Curtis, D. & Sham, P. C., 09/2008, In: Genetic Epidemiology. 32, 6, p. 539-545 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Design and analysis of association studies using pooled DNA from large twin samples

Knight, J. & Sham, P., 09/2006, In: Behavior Genetics. 36, 5, p. 665-677 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

Knight, J., North, B. V., Sham, P. C. & Curtis, D., 31/12/2003, In: Genetics. 4 , Suppl. 1, 4 p., S74.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Using functional annotation for the empirical determination of Bayes Factors for genome-wide association study analysis

Knight, J., Barnes, M. R., Breen, G. & Weale, M. E., 27/04/2011, In: PLoS ONE. 6, 4, 8 p., e14808.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

An investigation of candidate regions for association with bipolar disorder

Knight, J., Rochberg, N. S., Saccone, S. F., Nurnberger, J. I., Rice, J. P. & NIMH Genetics Initiative Bipolar Disorder Consortium, 5/10/2010, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics . 153B, 7, p. 1292-1297 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A comparison of association statistics between pooled and individual genotypes

Knight, J., Saccone, S. F., Zhang, Z., Ballinger, D. G. & Rice, J. P., 03/2009, In: Human Heredity. 67, 4, p. 219-225 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A survey of current software for genetic power calculations

Knight, J., 2/03/2004, In: BMC Genomics. 1, 3, p. 225-227 3 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Connected Health Cities – Lancaster – the north west coast and beyond

Knight, J. & King, N. S., 23/04/2018, In: Morecambe Bay Medical Journal. 7, 12, p. 310-310 1 p.

Research output: Contribution to Journal/Magazine › Journal article

Complex host genetics influence the microbiome in inflammatory bowel disease

Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., Tyler, A. D., van Sommeren, S., Imhann, F., Stempak, J. M., Huang, H., Vangay, P., Al-Ghalith, G. A., Russell, C., Sauk, J., Knight, J., Daly, M. J., Huttenhower, C. & Xavier, R. J., 2/12/2014, In: Genome Biology. 6, 12, 11 p., 107.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes

Langlois, A. W. R., El-Boraie, A., Fukunaga, K., Mushiroda, T., Kubo, M., Lerman, C., Knight, J., Scherer, S. E., Chenoweth, M. J. & Tyndale, R. F., 30/06/2022, In: Pharmacogenetics and genomics. 32, 4, p. 159-172 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review