Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen, L., Gustafsson, S., Wang, Q., Hansen, D. H., Hedman, Å. K., Schork, A., Page, K., Zhernakova, D. V., Wu, Y., Peters, J., Eriksson, N., Bergen, S. E., Boutin, T. S., Bretherick, A. D., Enroth, S., Kalnapenkis, A., Gådin, J. R., Suur, B. E., Chen, Y. & Matic, L. & 63 others, Gale, J. D., Lee, J., Zhang, W., Quazi, A., Ala-Korpela, M., Choi, S. H., Claringbould, A., Danesh, J., Davey Smith, G., de Masi, F., Elmståhl, S., Engström, G., Fauman, E., Fernandez, C., Franke, L., Franks, P. W., Giedraitis, V., Haley, C., Hamsten, A., Ingason, A., Johansson, Å., Joshi, P. K., Lind, L., Lindgren, C. M., Lubitz, S., Palmer, T., Macdonald-Dunlop, E., Magnusson, M., Melander, O., Michaelsson, K., Morris, A. P., Mägi, R., Nagle, M. W., Nilsson, P. M., Nilsson, J., Orho-Melander, M., Polasek, O., Prins, B., Pålsson, E., Qi, T., Sjögren, M., Sundström, J., Surendran, P., Võsa, U., Werge, T., Wernersson, R., Westra, H.-J., Yang, J., Zhernakova, A., Ärnlöv, J., Fu, J., Smith, J. G., Esko, T., Hayward, C., Gyllensten, U., Landen, M., Siegbahn, A., Wilson, J. F., Wallentin, L., Butterworth, A. S., Holmes, M. V., Ingelsson, E. & Mälarstig, A., 16/10/2020, In: Nature Metabolism. 2, 10, p. 1135-1148 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Statistics and the “little grey cells”

Jackson, J., 1/10/2020, In: Significance. 17, 5, p. 10-11 2 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A Critical Review of Graphics for Subgroup Analyses in Clinical Trials

Ballarini, N. M., Chiu, Y.-D., Koenig, F., Posch, M. & Jaki, T., 1/09/2020, In: Pharmaceutical Statistics. 19, 5, p. 541-560 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Covid-19 deaths: How are gender, age and underlying health condition related?

Jackson, J., 27/07/2020, In: Significance. 680.

Research output: Contribution to Journal/Magazine › Journal article

Discussion on the paper by Silverman (2020): James Jackson (Lancaster University)

Jackson, J., 1/06/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 3

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Estimation of treatment effects following a sequential trial of multiple treatments

Whitehead, J., Desai, Y. & Jaki, T., 20/05/2020, In: Statistics in Medicine. 39, 11, p. 1593-1609 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A benchmark for dose finding studies with continuous outcomes

Mozgunov, P., Jaki, T. F. & Paoletti, X., 1/04/2020, In: Biostatistics. 21, 2, p. 189–201 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A quantitative framework to inform extrapolation decisions in children

Wadsworth, I., Hampson, L. V., Jaki, T., Sills, G. J., Marson, A. G. & Appleton, R., 1/02/2020, In: Journal of the Royal Statistical Society: Series A Statistics in Society. 183, 2, p. 515-534 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Dynamic inference for non-Markov transition probabilities under random right-censoring

Dobler, D. & Titman, A. C., 14/01/2020, (E-pub ahead of print) In: Scandinavian Journal of Statistics. 47, 2, p. 572-586 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Confidentiality challenges in releasing longitudinally linked data

Mitra, R., Blanchard, S., Dove, I., Tudor, C. & Spicer, K., 2020, In: Transactions on Data Privacy. 13, 2, p. 151-170 20 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Subgroup analysis of treatment effects for misclassified biomarkers with time-to-event data

Wan, F., Titman, A. & Jaki, T., 1/11/2019, In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 5, p. 1447-1463 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A flexible design for advanced Phase I/II clinical trials with continuous efficacy endpoints

Mozgunov, P. & Jaki, T., 1/11/2019, In: Biometrical Journal. 61, 6, p. 1477-1492 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Loss Functions in Restricted Parameter Spaces and Their Bayesian Applications

Mozgunov, P., Jaki, T. F. & Gasparini, M., 3/10/2019, In: Journal of Applied Statistics. 46, 13, p. 2314-2337 24 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A novel measure of drug benefit–risk assessment based on Scale Loss Score

Saint-Hilary, G., Robert, V., Gasparini, M., Jaki, T. F. & Mozgunov, P., 1/09/2019, In: Statistical Methods in Medical Research. 28, 9, p. 2738-2753 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

‘Cost’ calculations as a barrier to gaining information under the Freedom of Information Act 2000 from the Police in England and Wales

Kingston, S. E., Elliott, A. & Thomas, T., 1/08/2019, In: Policing and Society: An International Journal of Research and Policy. 29, 7, p. 834-847 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A Bayesian model to estimate the cutoff and the clinical utility of a biomarker assay

Vradi, E., Jaki, T. F., Vonk, R. & Brannath, W., 1/08/2019, In: Statistical Methods in Medical Research. 28, 8, p. 2538-2556 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The effects of sample size on the estimation of regression mixture models

Jaki, T. F., Kim, M., Lamont, A. E., George, M., Feaster, D. & Van Horn, M. L., 1/04/2019, In: Educational and Psychological Measurement. 79, 2, p. 358-384 27 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Instrumental variable estimation in semi-parametric additive hazards models

Brueckner, M., Titman, A. C. & Jaki, T. F., 1/03/2019, In: Biometrics. 75, 1, p. 110-120 11 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Quantifying the association between progression-free survival and overall survival in oncology trials using Kendall's tau.

Weber, E. & Titman, A. C., 28/02/2019, In: Statistics in Medicine. 38, 5, p. 703-719 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The R package MAMS for designing multi-arm multi-stage clinical trials

Jaki, T. F., Pallmann, P. S. & Magirr, D., 31/01/2019, In: Journal of Statistical Software. 88, 4, 25 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A robust Bayesian meta-analytic approach to incorporate animal data into phase I oncology trials

Zheng, H., Hampson, L. V. & Wandel, S., 16/01/2019, (E-pub ahead of print) In: Statistical Methods in Medical Research. 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

An alternative method to analyse the Biomarker-strategy design

Kunz, C. U., Jaki, T. F. & Stallard, N., 30/12/2018, In: Statistics in Medicine. 37, 30, p. 4636-4651 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Design and estimation in clinical trials with subpopulation selection

Chiu, Y.-D., Koenig, F., Posch, M. & Jaki, T. F., 20/12/2018, In: Statistics in Medicine. 37, 29, p. 4335-4352 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

The role of the home environment in neurocognitive development of children living in extreme poverty and with frequent illnesses: a cross-sectional study

Nampijja, M., Kizindo, R., Apule, B., Lule, S. A., Muhangi, L., Titman, A., Elliott, A., Alcock, K. J. & Lewis, C. N., 3/12/2018, (E-pub ahead of print) In: Wellcome Open Research. 3, 17 p., 152.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Randomized dose-escalation designs for drug combination cancer trials with immunotherapy

Mozgunov, P., Jaki, T. F. & Paoletti, X., 23/10/2018, (E-pub ahead of print) In: Journal of Biopharmaceutical Statistics. 29, 2, p. 359-377 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries

Lancaster, G. A., McCray, G., Kariger, P., Dua, T., Titman, A., Chandna, J., McCoy, D., Abubakar, A., Hamadani, J. D., Fink, G., Tofail, F., Gladstone, M. & Janus, M., 16/10/2018, In: BMJ Global Health. 3, 5, 15 p., e000747.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal design when outcome values are not missing at random

Lee, K., Mitra, R. & Biedermann, S., 1/10/2018, In: Statistica Sinica. 28, 4, p. 1821-1838 18 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Software Application Profile: mrrobust - A Tool For Performing Two-Sample Summary Mendelian Randomization Analyses

Spiller, W., Davies, N. & Palmer, T. M., 12/09/2018, (E-pub ahead of print) In: International Journal of Epidemiology.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Performance of different clinical trial designs to evaluate treatments during an epidemic

Brueckner, M., Titman, A. C., Jaki, T. F., Rojek, A. & Horby, P. W., 11/09/2018, In: PLoS ONE. 13, 9, 19 p., e0203387.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bayesian spatial monotonic multiple regression

Rohrbeck, C., Costain, D. A. & Frigessi, A., 1/09/2018, In: Biometrika. 105, 3, p. 691-707 17 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A proposal for a new PhD level curriculum on quantitative methods for drug development

Jaki, T. F., Gordon, A., Forster, P. S., Bijnens, L., Bornkamp, B., Brannath, W., Fontana, R., Gasparini, M., Hampson, L. V., Jacobs, T., Jones, B., Paoletti, X., Posch, M., Titman, A. C., Vonk, R. & Koenig, F., 09/2018, In: Pharmaceutical Statistics. 17, 5, p. 593-606 14 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Dose-escalation strategies which utilise subgroup information

Cotterill, A. & Jaki, T. F., 09/2018, In: Pharmaceutical Statistics. 17, 5, p. 414-436 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Model selection based on combined penalties for biomarker identification

Vradi, E., Brannath, W., Jaki, T. & Vonk, R., 4/07/2018, In: Journal of Biopharmaceutical Statistics. 28, 4, p. 735-749 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

An information-theoretic Phase I/II design for molecularly targeted agents that does not require an assumption of monotonicity

Mozgunov, P. & Jaki, T. F., 15/06/2018, (E-pub ahead of print) In: Journal of the Royal Statistical Society: Series C (Applied Statistics). 68, 2, p. 347-367 21 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Attachment and therapeutic alliance in psychological therapy for people with recent onset psychosis who use cannabis

Berry, K., Palmer, T. M., Gregg, L., Barrowclough, C. & Lobban, A. F., 6/06/2018, In: Clinical Psychology and Psychotherapy. 25, 3, p. 440-445 6 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

UK Families with Children with Rare Chromosome Disorders: Changing Experiences of Diagnosis and Counseling (2003 to 2013)

Szczepura, A., Wynn, S., Searle, B., Khan, A., Palmer, T. M., Biggerstaff, D., Elliott, J. & Hulten, M., 05/2018, In: Clinical Genetics. 93, 5, p. 972-981 10 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Instrumental variable methods for a binary outcome were used to informatively address non-compliance in a randomised trial in surgery

Cook, J. A., Maclennan, G. S., Palmer, T., Lois, N. & Emsley, R., 04/2018, In: Journal of Clinical Epidemiology. 96, p. 126-132 7 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A review of the deterministic and diffusion approximations for stochastic chemical reaction networks

Mozgunov, P., Beccuti, M., Horvath, A., Jaki, T. F., Sirovich, R. & Bibbona, E., 04/2018, In: Reaction Kinetics, Mechanisms and Catalysis. 123, 2, p. 289-312 24 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Reading comprehension difficulties in children with rolandic epilepsy

Currie, N. K., Lew, A. R., Palmer, T. M., Basu, H., De Goede, C., Ayer, A. & Cain, K., 03/2018, In: Developmental Medicine and Child Neurology. 60, 3, p. 275-282 8 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

How effective and cost effective are innovative combinatorial technologies and practices for supporting older people with long-term conditions to remain well in the community? An evaluation protocol for an NHS Test Bed in North West England

Varey, S. E., Hernandez Huerta, M. A., Palmer, T. M., Mateus, C., Wilkinson, J., Dixon, M. P. & Milligan, C., 28/02/2018, In: BMJ Open. 8, 2, 10 p., e017268.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Extrapolation of efficacy and other data to support the development of new medicines for children: a systematic review of methods

Wadsworth, I., Hampson, L. V. & Jaki, T. F., 1/02/2018, In: Statistical Methods in Medical Research. 27, 2, p. 398-413 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer

Ghaneh, P., Hanson, R., Titman, A., Lancaster, G. A., Plumpton, C., Lloyd-Williams, H., Yeo, S. T., Edwards, R. T., Johnson, C., Abu Hilal, M., Higginson, A. P., Armstrong, T., Smith, A., Scarsbrook, A., McKay, C., Carter, R., Sutcliffe, R. P., Bramhall, S., Kocher, H. M. & Cunningham, D. & 20 others, Pereira, S. P., Davidson, B., Chang, D., Khan, S., Zealley, I., Sarker, D., Al Sarireh, B., Charnley, R., Lobo, D., Nicolson, M., Halloran, C., Raraty, M., Sutton, R., Vinjamuri, S., Evans, J., Campbell, F., Deeks, J., Sanghera, B., Wong, W.-L. & Neoptolemos, J. P., 02/2018, In: Health Technology Assessment. 22, 7, p. 1-114 114 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Identification of Predicted Individual Treatment Effects (PITE) in randomized clinical trials

Lamont, A. E., Lyons, M., Jaki, T. F., Stuart, E. A., Feaster, D., Ishwaran, H., Tharmaratnam, K. & Van Horn, M. L., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 142-157 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

A review of statistical updating methods for clinical prediction models

Su, T.-L., Jaki, T. F., Hickey, G., Buchan, I. & Sperrin, M., 1/01/2018, In: Statistical Methods in Medical Research. 27, 1, p. 185-197 13 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Optimal Designs for Non-Compartmental Analysis of Pharmacokinetic Studies

Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T. F., 2018, In: Statistics in Biopharmaceutical Research. 10, 4, p. 255-263 9 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Patterns of routine primary care for osteoarthritis in the UK: a cross-sectional electronic health records study

Jackson, H., Barnett, L., Jordan, K., Dziedzic, K., Cottrell, E., Finney, A., Paskins, Z. & Edwards, J., 29/12/2017, In: BMJ Open. 7, 12, 11 p., e019694.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Simultaneous confidence regions for multivariate bioequivalence

Pallmann, P. S. & Jaki, T. F., 20/12/2017, In: Statistics in Medicine. 36, 29, p. 4585-4603 19 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Simultaneous comparisons of treatments at multiple time points: combined marginal models versus joint modeling

Pallmann, P., Pretorius, M. & Ritz, C., 1/12/2017, In: Statistical Methods in Medical Research. 26, 6, p. 2633-2648 16 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Comparing sampling methods for pharmacokinetic studies using model averaged derived parameters

Barnett, H. Y., Geys, H., Jacobs, T. & Jaki, T., 30/11/2017, In: Statistics in Medicine. 36, 27, p. 4301-4315 15 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Patterns of infant mortality in rural England and Wales, 1850-1910

Atkinson, P. D., Francis, B. J., Gregory, I. N. & Porter, C., 1/11/2017, In: Economic History Review. 70, 4, p. 1268-1290 23 p.

Research output: Contribution to Journal/Magazine › Journal article › peer-review